禁止可遗传性转基因治疗？
http://www.100md.com
2000年9月21日
Science Group: Ban Gene Modification
Tuesday, September 19, 2000
WASHINGTON — The modification of human genes that can be passed to future generations is not safe at this time and should not be undertaken, the world's largest federation of scientists reported Monday.
In a long-awaited report on human inheritable genetic modifications, known as IGM, the American Association for the Advancement of Science (AAAS) said no human trials of this kind of gene therapy should occur until standards and stringent oversight are in place.
The idea behind such research would be to free families of inherited genetic disorders, but by modifying inheritable genes — those in a patient's sperm or eggs — the therapy could introduce new genetic problems that would in turn be passed along to new generations.
The report noted that researchers have been successful in some cases with somatic gene therapy, which deals only with genes that cannot be inherited. But what works in somatic gene therapy will not now work to treat inherited genetic ills.
"IGM utilizing current methods for somatic gene transfer cannot presently be carried out responsibly to humans," Dr. Mark Frankel, the report's co-author, said in a statement.
Aside from strictly medical questions, the issues of ethics and religion come into play on this matter, the report said.
"IGM might change attitudes toward the human person, the nature of human reproduction, and parent-child relationships," the scientists reported.
"IGM could exacerbate prejudice against persons with disabilities. The introduction of IGM in a society with differential access to health care would pose significant justice issues and could introduce new, or magnify existing inequalities," the report said.
If there is ultimately "a societal decision" to go ahead with IGM research, "The ethical and social issues are sufficiently compelling to justify government oversight in this case," Frankel said.
There should also be "a meaningful dialogue" with the American public, the scientists reported., 百拇医药
Tuesday, September 19, 2000
WASHINGTON — The modification of human genes that can be passed to future generations is not safe at this time and should not be undertaken, the world's largest federation of scientists reported Monday.
In a long-awaited report on human inheritable genetic modifications, known as IGM, the American Association for the Advancement of Science (AAAS) said no human trials of this kind of gene therapy should occur until standards and stringent oversight are in place.
The idea behind such research would be to free families of inherited genetic disorders, but by modifying inheritable genes — those in a patient's sperm or eggs — the therapy could introduce new genetic problems that would in turn be passed along to new generations.
The report noted that researchers have been successful in some cases with somatic gene therapy, which deals only with genes that cannot be inherited. But what works in somatic gene therapy will not now work to treat inherited genetic ills.
"IGM utilizing current methods for somatic gene transfer cannot presently be carried out responsibly to humans," Dr. Mark Frankel, the report's co-author, said in a statement.
Aside from strictly medical questions, the issues of ethics and religion come into play on this matter, the report said.
"IGM might change attitudes toward the human person, the nature of human reproduction, and parent-child relationships," the scientists reported.
"IGM could exacerbate prejudice against persons with disabilities. The introduction of IGM in a society with differential access to health care would pose significant justice issues and could introduce new, or magnify existing inequalities," the report said.
If there is ultimately "a societal decision" to go ahead with IGM research, "The ethical and social issues are sufficiently compelling to justify government oversight in this case," Frankel said.
There should also be "a meaningful dialogue" with the American public, the scientists reported., 百拇医药
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