家族史、吸烟提高胰腺癌发病率
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2001年4月28日
NEW YORK (Reuters Health) - Having a close relative with cancer of the pancreas significantly increases an individual's chance of developing the disease, especially if that person smokes, researchers report.
Previous studies that looked at factors associated with pancreatic cancer have consistently identified only increasing age and smoking as major risks, according to researchers led by Dr. Maryjean Schenk from Wayne State University in Detroit, Michigan.
Schenk and her colleagues interviewed 247 patients with cancer of the pancreas and 420 people without cancer to determine whether any of their parents or siblings also had the disease.
Having a close relative with pancreatic cancer increased one's chance of developing the disease by 2.5 times, the authors report in the April 18th issue of the Journal of the National Cancer Institute (news - web sites).
And the risk was much higher for those individuals who not only had a family member with pancreatic cancer, but who also smoked. Their risk, the researchers found, was six times higher than that faced by people without these two risk factors. In addition, the risk grew to eightfold higher if the relative had developed pancreatic cancer before age 60.
``To our knowledge,'' the authors write, ``this study is the first to suggest that the age of onset of pancreatic cancer in close relatives is an important contributing risk factor of pancreatic cancer in people who smoke.''
Abstinence from smoking, Schenk told Reuters Health, is even more important for individuals in families with a history of pancreatic cancer.
SOURCE: Journal of the National Cancer Institute 2001;93:640-644., 百拇医药
Previous studies that looked at factors associated with pancreatic cancer have consistently identified only increasing age and smoking as major risks, according to researchers led by Dr. Maryjean Schenk from Wayne State University in Detroit, Michigan.
Schenk and her colleagues interviewed 247 patients with cancer of the pancreas and 420 people without cancer to determine whether any of their parents or siblings also had the disease.
Having a close relative with pancreatic cancer increased one's chance of developing the disease by 2.5 times, the authors report in the April 18th issue of the Journal of the National Cancer Institute (news - web sites).
And the risk was much higher for those individuals who not only had a family member with pancreatic cancer, but who also smoked. Their risk, the researchers found, was six times higher than that faced by people without these two risk factors. In addition, the risk grew to eightfold higher if the relative had developed pancreatic cancer before age 60.
``To our knowledge,'' the authors write, ``this study is the first to suggest that the age of onset of pancreatic cancer in close relatives is an important contributing risk factor of pancreatic cancer in people who smoke.''
Abstinence from smoking, Schenk told Reuters Health, is even more important for individuals in families with a history of pancreatic cancer.
SOURCE: Journal of the National Cancer Institute 2001;93:640-644., 百拇医药