Gb 病毒C也许抑制Hiv复制
WESTPORT, CT (Reuters Health) - Two reports in The New England Journal of Medicine for September 6 suggest that infection with the GB virus C--also known as the hepatis G virus--improves survival in patients infected with HIV by directly influencing HIV replication.
In what Dr. Daniel J. Diekema told Reuters Health were the largest studies to date, researchers confirmed previous reports that coinfection with GB virus C is associated with a decrease in the mortality rate among HIV-infected individuals, slower progression to AIDS, and longer survival after AIDS has developed (see Reuters Health reports, June 21, 2000, and March 31, 1999).
Dr. Diekema, of the University of Iowa College of Medicine in Iowa City, and colleagues followed 362 HIV-infected patients, including 144 with GB virus C viremia and 218 who tested negative for GB virus C. The adjusted relative risk of death over a mean of 4.1 years in the GB virus C-negative group was 3.7 compared with those testing positive for the virus.
The investigators also conducted in vitro studies using peripheral-blood mononuclear cells infected with each virus alone and with the two viruses together. Cells infected with GB virus C 24 hours before being infected with HIV demonstrated 99.0% reduction of HIV replication by 6 days after infection.
Co-collaborator Dr. Sabina W黱schmann discussed the results with Reuters Health, saying, "If a cell is already infected with GB virus C, then HIV attempting to superinfect the same cell may be unable to use the cell machinery for its own replication because it's already taken."
Another theory, she said, is that GB virus C replication induces production of soluble cellular factors, such as cytokines or type 1 interferons, that prevent HIV replication., 百拇医药
In what Dr. Daniel J. Diekema told Reuters Health were the largest studies to date, researchers confirmed previous reports that coinfection with GB virus C is associated with a decrease in the mortality rate among HIV-infected individuals, slower progression to AIDS, and longer survival after AIDS has developed (see Reuters Health reports, June 21, 2000, and March 31, 1999).
Dr. Diekema, of the University of Iowa College of Medicine in Iowa City, and colleagues followed 362 HIV-infected patients, including 144 with GB virus C viremia and 218 who tested negative for GB virus C. The adjusted relative risk of death over a mean of 4.1 years in the GB virus C-negative group was 3.7 compared with those testing positive for the virus.
The investigators also conducted in vitro studies using peripheral-blood mononuclear cells infected with each virus alone and with the two viruses together. Cells infected with GB virus C 24 hours before being infected with HIV demonstrated 99.0% reduction of HIV replication by 6 days after infection.
Co-collaborator Dr. Sabina W黱schmann discussed the results with Reuters Health, saying, "If a cell is already infected with GB virus C, then HIV attempting to superinfect the same cell may be unable to use the cell machinery for its own replication because it's already taken."
Another theory, she said, is that GB virus C replication induces production of soluble cellular factors, such as cytokines or type 1 interferons, that prevent HIV replication., 百拇医药