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Dad And Mom Play Role In Pregnancy Complication
http://www.100md.com 2001年4月8日 三九健康网
     NEW YORK, Mar 21 (Reuters Health) - A woman's risk of developing dangerously high blood pressure during pregnancy may be determined while she--or the baby's father--are still in their own mother's womb, recent study findings suggest.

    According to the report in the March 22nd issue of The New England Journal of Medicine, men and women whose mothers had preeclampsia were significantly more likely to have a child who suffered from the pregnancy-related complication.
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    While researchers have known that women whose mothers had the condition are at increased risk, they have not known whether there is a paternal component. Preeclampsia is a condition marked by high blood pressure and swelling of the body due to fluid accumulation. If it is not treated, the condition can lead to convulsions, coma and death of the mother or fetus.

    An estimated 50,000 women worldwide die from the disorder each year, Dr. Fiona Broughton Pipkin from the University of Nottingham, UK, notes in an editorial.
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    In the study, investigators found that men whose mothers had preeclampsia were more than twice as likely to have a child whose birth was complicated by the condition. Women born to mothers with preeclampsia were more than three times as likely to develop the condition during their own pregnancies, the report indicates.

    The findings suggest that the father can pass along a genetic component to the fetus that puts the mother at risk.
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    "These findings support the hypothesis that the genotype of the fetus contributes to the overall risk of preeclampsia," according to Dr. M. Sean Esplin from the University of Utah in Salt Lake City, and colleagues.

    Indeed, other studies have shown that paternal genes play a key role in the development of the placenta. While the causes of preeclampsia are not clear, it may be partly due to the failure of the placenta to attach to the uterus. Women who carry genetic mutations predisposing them to blood-clotting disorders also appear to be at increased risk.
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    "We found evidence of both paternal and maternal components of the predisposition to preeclampsia, supporting the theory that genetic contributions from both parents are important in the development of the disorder," the researchers conclude.

    But Pipkin cautions that it is not possible to know who is at risk.

    "The ability to study this predisposition is hampered by the obvious fact that preeclampsia is a disease of pregnancy and no markers for the disorder have yet been identified in nonpregnant women, let alone men," the editorialist writes.

    The study findings are based on an analysis of hospital records of 298 men and 237 women born between 1947 and 1957 whose mothers had preeclampsia, and individuals born during the same time whose mothers did not have preeclampsia.

    The New England Journal of Medicine 2001, 百拇医药