维生素A可以降低结肠直肠腺瘤的发病
【摘要】德国研究者指出：血液中含有高浓度的维生素A，有助于阻断结肠直肠腺瘤的发病，而含有维生素C和维生素E却不能起到阻止瘤细胞生长的作用。 【全文】Vitamin A Reduces Risk Of Colorectal Adenoma02/23/2001By Jonathan PayneHigh vitamin A serum concentrations may block the pathogenesis of colorectal adenomas. The antioxidant vitamins C and E, and carotene, however, do not prevent development of those tumors, say German investigators.The Colorectal Adenoma Study Group at Essen University Hospital exploring the relationship between colorectal adenoma and serum levels of the vitamins in a population-based case-control study involving 105 patients with colorectal adenoma versus a similar number of polyp-free hospital and population controls. They were unable to find any significant association between serum concentrations of vitamin C, E or carotene with the development of adenomatous tumors. Higher serum concentrations of vitamin A, however, were significantly associated with a reduced risk of colorectal adenomas compared to both control groups. And after adjusting for energy intake, smoking, alcohol consumption, estrogen therapy, body mass index and social class, the investigators found that the inverse association between vitamin A and colorectal carcinoma was even more striking. "For the highest versus the lowest quartile of serum (vitamin A) levels the adjusted risk ratio was 0.23 in relation to hospital controls and 0.08 in relation to population controls," said the researchers, who are attached to the Department of Gastroenterology at the Center of Internal Medicine.While there was no significant association between serum levels of vitamins C and E or carotene and colorectal adenoma, the results suggest that the risk of colorectal adenomas is reduced with high serum levels of vitamin A., 百拇医药
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