激素替代疗法不能完全防止骨质疏松
http://www.100md.com
2001年1月15日
路透社纽约健康消息 激素代替疗法过去一直被认为有助于防止绝经期后由于衰老所致的骨质疏松，然而一项新的研究却发现仍有部份参与该治疗的女性继续发生骨质疏松。
以洛杉矶加利福尼亚大学博士吉尔·格里恩代尔为首的研究小组对670名妇女进行了研究，其中538位正在接受激素替代疗法，另外132位则并未使用任何激素。结果发现，在接受激素替代疗法的第一年，约5%的妇女下部脊骨骨质至少丢失1%；15%的妇女臀部骨质至少丢失1%；疗程的第二至第三年，8%的妇女出现脊骨骨质丢失；12%的妇女出现髋骨骨质丢失。此外，没有用激素的女性有60%发生了骨质丢失。
研究小组认为：在接受激素替代疗法的妇女中发生骨质损失的比例很少，估计其中10%至30%是接受了非正规性治疗，这并不意味着对这些女性的治疗失败。如果没有接受激素替代疗法，她们骨损失的程度可能会更严重。当进行激素替代疗法时，高龄是导致骨质掉失的最重要的危险因素，相对年轻的女人较少发生骨损失。
, 百拇医药
研究小组还指出，骨损失可分为两种类型：即骨损失发生在激素治疗的第一年或第二至第三年，很少女性骨损失同时发生在这两个时期；女性在激素替代治疗的第一年出现骨质增加或减少并不意味着这种情况今后仍会持续。某些女性在治疗的第一年出现骨损失，而另外一些妇女骨损失则发生在激素治疗的第二或第三年。
Some Women Lose Bone While Taking Hormones
NEW YORK (Reuters Health) - Hormone replacement therapy is thought to help prevent bone loss due to aging when taken after menopause. However, new study findings show that at least some women continue to lose bone when taking hormones.
, 百拇医药
About 5% of women on hormone therapy lost at least 1% of bone mass in the lower spine within the first year of treatment, and 15% of women lost at least 1% of hip bone mass. During the second and third years, 8% of women lost spinal bone mass, while 12% lost hip bone mass.
The study included 538 women taking hormones and 132 women who were not taking any hormones, according to the report in the November 13th issue of the journal Archives of Internal Medicine.
, 百拇医药
But such bone loss is rare and does not necessarily mean that the treatment has failed in these women. It is possible that they would have lost even more bone mass if they had not started taking hormones, according to the team of researchers led by Dr. Gail A. Greendale, of the University of California, Los Angeles.
It has been thought that some women lose bone mass while taking hormone replacement, but the estimates, ranging from 10% to 30% of women, have been informal, according to the researchers.
, 百拇医药
Overall, older age was the most important risk factor for losing bone while on hormone replacement therapy. The researchers report that there appeared to be two groups of women who lost bone mass--those who lost bone mass during the first year and those who lost during the second and third years. Few women lost bone during both periods.
Not surprisingly, many of the women not taking hormone therapy lost bone, but about 40% of these women did not lose any bone mass during the study, the authors point out.
, 百拇医药
The study has several important implications, according to Greendale and her colleagues. They note that bone loss is rare in relatively young women who take hormone therapy after menopause.
The team also points out that whether a woman gains or loses bone mass during the first year of taking hormone replacement therapy is not a good indication of whether she will continue to gain or lose bone. Some women stop losing bone after the first year of treatment while others begin losing bone in the second or third year, they note.
SOURCE: Archives of Internal Medicine 2000;160:3065-3071.
载自家庭医生医疗保健网, 百拇医药
以洛杉矶加利福尼亚大学博士吉尔·格里恩代尔为首的研究小组对670名妇女进行了研究，其中538位正在接受激素替代疗法，另外132位则并未使用任何激素。结果发现，在接受激素替代疗法的第一年，约5%的妇女下部脊骨骨质至少丢失1%；15%的妇女臀部骨质至少丢失1%；疗程的第二至第三年，8%的妇女出现脊骨骨质丢失；12%的妇女出现髋骨骨质丢失。此外，没有用激素的女性有60%发生了骨质丢失。
研究小组认为：在接受激素替代疗法的妇女中发生骨质损失的比例很少，估计其中10%至30%是接受了非正规性治疗，这并不意味着对这些女性的治疗失败。如果没有接受激素替代疗法，她们骨损失的程度可能会更严重。当进行激素替代疗法时，高龄是导致骨质掉失的最重要的危险因素，相对年轻的女人较少发生骨损失。
, 百拇医药
研究小组还指出，骨损失可分为两种类型：即骨损失发生在激素治疗的第一年或第二至第三年，很少女性骨损失同时发生在这两个时期；女性在激素替代治疗的第一年出现骨质增加或减少并不意味着这种情况今后仍会持续。某些女性在治疗的第一年出现骨损失，而另外一些妇女骨损失则发生在激素治疗的第二或第三年。
Some Women Lose Bone While Taking Hormones
NEW YORK (Reuters Health) - Hormone replacement therapy is thought to help prevent bone loss due to aging when taken after menopause. However, new study findings show that at least some women continue to lose bone when taking hormones.
, 百拇医药
About 5% of women on hormone therapy lost at least 1% of bone mass in the lower spine within the first year of treatment, and 15% of women lost at least 1% of hip bone mass. During the second and third years, 8% of women lost spinal bone mass, while 12% lost hip bone mass.
The study included 538 women taking hormones and 132 women who were not taking any hormones, according to the report in the November 13th issue of the journal Archives of Internal Medicine.
, 百拇医药
But such bone loss is rare and does not necessarily mean that the treatment has failed in these women. It is possible that they would have lost even more bone mass if they had not started taking hormones, according to the team of researchers led by Dr. Gail A. Greendale, of the University of California, Los Angeles.
It has been thought that some women lose bone mass while taking hormone replacement, but the estimates, ranging from 10% to 30% of women, have been informal, according to the researchers.
, 百拇医药
Overall, older age was the most important risk factor for losing bone while on hormone replacement therapy. The researchers report that there appeared to be two groups of women who lost bone mass--those who lost bone mass during the first year and those who lost during the second and third years. Few women lost bone during both periods.
Not surprisingly, many of the women not taking hormone therapy lost bone, but about 40% of these women did not lose any bone mass during the study, the authors point out.
, 百拇医药
The study has several important implications, according to Greendale and her colleagues. They note that bone loss is rare in relatively young women who take hormone therapy after menopause.
The team also points out that whether a woman gains or loses bone mass during the first year of taking hormone replacement therapy is not a good indication of whether she will continue to gain or lose bone. Some women stop losing bone after the first year of treatment while others begin losing bone in the second or third year, they note.
SOURCE: Archives of Internal Medicine 2000;160:3065-3071.
载自家庭医生医疗保健网, 百拇医药
参见：首页 > 医疗版 > 疾病专题 > 内分泌科 > 下丘脑-垂体疾病 > 骨质疏松症