P物质：痛并快乐着
Murtra etal.报道P物质可能与痛觉截然相反的现象－愉悦刺激有关。
Murtra etal.发现神经激肽－1在小鼠脑内主要表达于丝状体复合物，包括nucleus
basalis和nucleus accumbens，这些区域已知是与自然奖励刺激(natural
reward stimuli)有关的。他们进一步将神经激肽－1敲除小鼠用吗啡刺激，对照组小鼠对存在吗啡的地区有更多的倾向性，而突变组似乎蛮不在乎，在去除吗啡后，突变组小鼠表现的药物依赖性也比对照组小得多。
他们的工作证明，P物质与介导自然奖励反应有关。这些发现揭示了P物质拮抗剂在对待吗啡成瘾问题上的可能用途，由于突变组的鸦片镇痛基本完整保留，那么将鸦片类药物与P物质拮抗剂共同给药，是否能减轻镇痛剂的成瘾性呢?
Section of a mouse brain
stained with an antibody against neurokinin-1. The receptor is mostly
expressed in the striatal complex, including the nucleus accumbens.
Image courtesy of C. Gadd, P. Murtra & S. Hunt (University College
London).
相关文章：
Original research paper
Murtra, P., Sheasby, A. M., Hunt, S. P. & De
Felipe, C. Rewarding effects of opiates are absent in mice lacking the
receptor for substance P. Nature 405, 180–183 (2000). REVIEWS
Koob, G. F., Sanna, P. P. & Bloom, F. E. Neuroscience of addiction. Neuron 21, 467–476 (1998).
Mogil, J. S., Yu, L. & Basbaum, A. I. Pain genes?:
Natural variation and transgenic mutants. Annu. Rev. Neurosci. 23,777–811 (2000).
Further reading
De Felipe, C. et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 392,394–397 (2000).
Nichols, M. L. et al. Transmission of chronic Nociception by spinal neurons expressing the substance P receptor.
Science 286, 1558–1561 (1999).
新思路
新技术—其他文章, http://www.100md.com
Murtra etal.发现神经激肽－1在小鼠脑内主要表达于丝状体复合物，包括nucleus
basalis和nucleus accumbens，这些区域已知是与自然奖励刺激(natural
reward stimuli)有关的。他们进一步将神经激肽－1敲除小鼠用吗啡刺激，对照组小鼠对存在吗啡的地区有更多的倾向性，而突变组似乎蛮不在乎，在去除吗啡后，突变组小鼠表现的药物依赖性也比对照组小得多。
他们的工作证明，P物质与介导自然奖励反应有关。这些发现揭示了P物质拮抗剂在对待吗啡成瘾问题上的可能用途，由于突变组的鸦片镇痛基本完整保留，那么将鸦片类药物与P物质拮抗剂共同给药，是否能减轻镇痛剂的成瘾性呢?
Section of a mouse brain
stained with an antibody against neurokinin-1. The receptor is mostly
expressed in the striatal complex, including the nucleus accumbens.
Image courtesy of C. Gadd, P. Murtra & S. Hunt (University College
London).
相关文章：
Original research paper
Murtra, P., Sheasby, A. M., Hunt, S. P. & De
Felipe, C. Rewarding effects of opiates are absent in mice lacking the
receptor for substance P. Nature 405, 180–183 (2000). REVIEWS
Koob, G. F., Sanna, P. P. & Bloom, F. E. Neuroscience of addiction. Neuron 21, 467–476 (1998).
Mogil, J. S., Yu, L. & Basbaum, A. I. Pain genes?:
Natural variation and transgenic mutants. Annu. Rev. Neurosci. 23,777–811 (2000).
Further reading
De Felipe, C. et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 392,394–397 (2000).
Nichols, M. L. et al. Transmission of chronic Nociception by spinal neurons expressing the substance P receptor.
Science 286, 1558–1561 (1999).
新思路
新技术—其他文章, http://www.100md.com