胖妈妈得糖尿病，生孩子先天缺陷多
路透社纽约健康消息-最近有研究发现，患有Ⅱ型糖尿病的肥胖女性产出先天缺陷婴儿的可能性是正常女性的三倍之高。肥胖症定义为身体的质量指数(BMI)等于或大于28。BMI是测量人体身高和体重的指数。
根据11月的《流行病学杂志》上发表的研究结果，这些高危女性生产出有先天缺陷的婴儿的危险性的确很高，尤其是生产出唇裂等颅面缺陷儿或肢体畸形儿的可能性会是正常妇女高七倍以上。肥胖和糖尿病可能是通过联合作用致使婴儿出生畸形的，因为在先天缺陷婴儿的母亲中，大约有65%患有糖尿病和肥胖症，且为两种病相互作用引起的。
在Ⅱ型糖尿病妇女中，6%所生产的婴儿是有明显的缺陷的，而这个比例在无糖尿病的妇女中则是1.34%。研究还发现，新生儿中颅面、骨骼及肌肉相关的缺陷是最常见的。虽然某些类型的缺陷很常见，但只患有肥胖症的妇女的新生儿有先天缺陷的并不比常人多。同样，体重正常，而在怀孕期间患上糖尿病的妇女，新生儿先天缺陷的现象也不比常人多。
, 百拇医药
研究结果是对23000名妇女的资料进行分析研究得出的，该结果支持其他有关母亲患肥胖症及Ⅱ型糖尿病会引发婴儿先天缺陷的研究的结论。
来源：《流行病学》2000;11:689-694
Obesity, Diabetes Ups Risk of Birth Defects
NEW YORK (Reuters Health) - Obese women who also have type 2 diabetes are about three times more likely than non-obese non-diabetic women to deliver a child with a birth defect, researchers report.
These at-risk women were at greatest risk--seven times more likely--of giving birth to a child with a craniofacial defect such as cleft palate, or abnormal limb development, according to findings published in the November issue of Epidemiology.
, http://www.100md.com
According to the study authors, obesity and diabetes may act in combination to raise the risk of birth defects. About 65% of major birth defects among women who were both obese and diabetic were caused by the interaction of these two factors, the investigators estimate.
``We found that the joint exposure to obesity and diabetes led to a threefold increased risk of all major defects,‘‘ according to Dr. Lynn L. Moore and colleagues from the Boston University School of Medicine in Massachusetts.
, http://www.100md.com
The study defined obesity as a body mass index (BMI) of at least 28. BMI is a measure of a person‘s weight in relation to their height.
Nearly 6% of all women with type 2 diabetes had babies with major defects, compared with 1.34% of women without diabetes. Craniofacial and musculoskeletal defects were the most common types of problems, researchers found.
Obese women without diabetes were not more likely to deliver a child with a birth defect, although certain types of defects were more common. Similarly, normal-weight women with gestational diabetes, which occurs during pregnancy, were not at increased risk of having children with major defects.
The results of the study are based on data from nearly 23,000 women.
The current findings support observations made in other studies suggesting that maternal obesity and type 2 diabetes raise the risk of congenital defects.
SOURCE: Epidemiology 2000;11:689-694., 百拇医药
根据11月的《流行病学杂志》上发表的研究结果，这些高危女性生产出有先天缺陷的婴儿的危险性的确很高，尤其是生产出唇裂等颅面缺陷儿或肢体畸形儿的可能性会是正常妇女高七倍以上。肥胖和糖尿病可能是通过联合作用致使婴儿出生畸形的，因为在先天缺陷婴儿的母亲中，大约有65%患有糖尿病和肥胖症，且为两种病相互作用引起的。
在Ⅱ型糖尿病妇女中，6%所生产的婴儿是有明显的缺陷的，而这个比例在无糖尿病的妇女中则是1.34%。研究还发现，新生儿中颅面、骨骼及肌肉相关的缺陷是最常见的。虽然某些类型的缺陷很常见，但只患有肥胖症的妇女的新生儿有先天缺陷的并不比常人多。同样，体重正常，而在怀孕期间患上糖尿病的妇女，新生儿先天缺陷的现象也不比常人多。
, 百拇医药
研究结果是对23000名妇女的资料进行分析研究得出的，该结果支持其他有关母亲患肥胖症及Ⅱ型糖尿病会引发婴儿先天缺陷的研究的结论。
来源：《流行病学》2000;11:689-694
Obesity, Diabetes Ups Risk of Birth Defects
NEW YORK (Reuters Health) - Obese women who also have type 2 diabetes are about three times more likely than non-obese non-diabetic women to deliver a child with a birth defect, researchers report.
These at-risk women were at greatest risk--seven times more likely--of giving birth to a child with a craniofacial defect such as cleft palate, or abnormal limb development, according to findings published in the November issue of Epidemiology.
, http://www.100md.com
According to the study authors, obesity and diabetes may act in combination to raise the risk of birth defects. About 65% of major birth defects among women who were both obese and diabetic were caused by the interaction of these two factors, the investigators estimate.
``We found that the joint exposure to obesity and diabetes led to a threefold increased risk of all major defects,‘‘ according to Dr. Lynn L. Moore and colleagues from the Boston University School of Medicine in Massachusetts.
, http://www.100md.com
The study defined obesity as a body mass index (BMI) of at least 28. BMI is a measure of a person‘s weight in relation to their height.
Nearly 6% of all women with type 2 diabetes had babies with major defects, compared with 1.34% of women without diabetes. Craniofacial and musculoskeletal defects were the most common types of problems, researchers found.
Obese women without diabetes were not more likely to deliver a child with a birth defect, although certain types of defects were more common. Similarly, normal-weight women with gestational diabetes, which occurs during pregnancy, were not at increased risk of having children with major defects.
The results of the study are based on data from nearly 23,000 women.
The current findings support observations made in other studies suggesting that maternal obesity and type 2 diabetes raise the risk of congenital defects.
SOURCE: Epidemiology 2000;11:689-694., 百拇医药
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