化疗脱发恼人 药物预防有望
路透社纽约健康消息 据报导，科学家们在寻找防止化疗所致脱发的研究中取得一项新的突破，这种还在试验阶段的化合物能让接受化疗的实验鼠毛发脱落减少高达50%。
许多化疗药物是通过攻击能迅速分裂的靶细胞来起作用的，这些细胞包括癌细胞。但是因为头发的毛囊细胞也分裂迅速，而化疗药物并不能区分癌细胞和正常增殖的细胞，所以化疗常常会出现脱发的不良副作用。虽然医学专家认为这种由化疗引起的脱发是可逆的，但是秃发的样子确实惹人注目，往往令患者感到尴尬和烦恼，无助感倍增，使他们丧失治愈疾病的信心。
一种被命名为CDK2的酶是开启细胞分裂过程的闸门，美国的研究员最近发现了一种以CDK2为攻击目标的化合物，他们希望通过阻断这种酶来达到防止化疗后脱发的目的。在大鼠身上进行的试验发现，当将CDK抑制剂应用到经过一般化疗的大鼠的头皮上时，大鼠的毛发的脱落减少了33%到50%。由于这种化合物防止脱发的作用仅发生在用药的局部，对大鼠的其它部位则没有作用，因此它不会干扰化疗的抗癌作用。
, http://www.100md.com
这项研究只是迈出了可喜的第一步。在上述动物试验的基础上，有关方面将会批准在癌症患者中进行临床试验，以评估该药在防止化疗诱发的秃发方面的功效。但是，这种化合物在进行人体试验前还必须在动物中进行更多的安全测试。
来源：《科学》2001;291:134-137
Compounds Prevent Chemotherapy-Induced Hair Loss
NEW YORK (Reuters Health) - Scientists reported Thursday that they had made a breakthrough in the search for a way to prevent the hair loss that is a common and distressing side effect of chemotherapy. They showed that an experimental compound reduced hair loss by up to 50% in rats given chemotherapy.
, 百拇医药
Many chemotherapy drugs work by targeting cells that are dividing rapidly, including cancer cells. But because cells in hair follicles also divide frequently, an unwanted side effect of treatment is often hair loss.
``Chemotherapy does not distinguish between cancer and normal proliferating cells,‘‘ the study‘s lead author, Dr. Stephen T. Davis, of Glaxo Wellcome Research and Development in Research Triangle Park, North Carolina, told Reuters Health.
, 百拇医药
Davis and his colleagues developed compounds that target an enzyme called CDK2, which is a switch for turning on the cell-division process. By blocking this enzyme, the researchers hoped to prevent chemotherapy-induced hair loss.
The results of tests in rats look promising, the authors report in the January 5th issue of the journal Science. When a CDK inhibitor was applied to the scalps of rats that were undergoing common types of chemotherapy, hair loss was reduced in 33% to 50% of the animals.
, 百拇医药
The research is the first step in an ``exciting path of drug discovery,‘‘ according to Davis. He noted that the compounds prevented hair loss only in the spots where they were applied, not in other parts of the rats‘ bodies, suggesting that they would not interfere with the cancer-fighting abilities of chemotherapy.
``Although chemotherapy-induced alopecia (hair loss) is considered a reversible side effect, the traumatic visual reminder and the stigma...reinforces a sense of helplessness and the perception that the patient may not survive his or her disease,‘‘ Davis and his colleagues write.
, 百拇医药
``On the basis of the evidence presented here, clinical trials in cancer patients to assess the efficacy of this approach to prevent chemotherapy-induced alopecia may be warranted,‘‘ the authors conclude.
But despite the promising preliminary results, Davis said that the compounds used in the study must undergo further safety tests in animals before they can be tested in human clinical trials.
SOURCE: Science 2001;291:134-137., 百拇医药
许多化疗药物是通过攻击能迅速分裂的靶细胞来起作用的，这些细胞包括癌细胞。但是因为头发的毛囊细胞也分裂迅速，而化疗药物并不能区分癌细胞和正常增殖的细胞，所以化疗常常会出现脱发的不良副作用。虽然医学专家认为这种由化疗引起的脱发是可逆的，但是秃发的样子确实惹人注目，往往令患者感到尴尬和烦恼，无助感倍增，使他们丧失治愈疾病的信心。
一种被命名为CDK2的酶是开启细胞分裂过程的闸门，美国的研究员最近发现了一种以CDK2为攻击目标的化合物，他们希望通过阻断这种酶来达到防止化疗后脱发的目的。在大鼠身上进行的试验发现，当将CDK抑制剂应用到经过一般化疗的大鼠的头皮上时，大鼠的毛发的脱落减少了33%到50%。由于这种化合物防止脱发的作用仅发生在用药的局部，对大鼠的其它部位则没有作用，因此它不会干扰化疗的抗癌作用。
, http://www.100md.com
这项研究只是迈出了可喜的第一步。在上述动物试验的基础上，有关方面将会批准在癌症患者中进行临床试验，以评估该药在防止化疗诱发的秃发方面的功效。但是，这种化合物在进行人体试验前还必须在动物中进行更多的安全测试。
来源：《科学》2001;291:134-137
Compounds Prevent Chemotherapy-Induced Hair Loss
NEW YORK (Reuters Health) - Scientists reported Thursday that they had made a breakthrough in the search for a way to prevent the hair loss that is a common and distressing side effect of chemotherapy. They showed that an experimental compound reduced hair loss by up to 50% in rats given chemotherapy.
, 百拇医药
Many chemotherapy drugs work by targeting cells that are dividing rapidly, including cancer cells. But because cells in hair follicles also divide frequently, an unwanted side effect of treatment is often hair loss.
``Chemotherapy does not distinguish between cancer and normal proliferating cells,‘‘ the study‘s lead author, Dr. Stephen T. Davis, of Glaxo Wellcome Research and Development in Research Triangle Park, North Carolina, told Reuters Health.
, 百拇医药
Davis and his colleagues developed compounds that target an enzyme called CDK2, which is a switch for turning on the cell-division process. By blocking this enzyme, the researchers hoped to prevent chemotherapy-induced hair loss.
The results of tests in rats look promising, the authors report in the January 5th issue of the journal Science. When a CDK inhibitor was applied to the scalps of rats that were undergoing common types of chemotherapy, hair loss was reduced in 33% to 50% of the animals.
, 百拇医药
The research is the first step in an ``exciting path of drug discovery,‘‘ according to Davis. He noted that the compounds prevented hair loss only in the spots where they were applied, not in other parts of the rats‘ bodies, suggesting that they would not interfere with the cancer-fighting abilities of chemotherapy.
``Although chemotherapy-induced alopecia (hair loss) is considered a reversible side effect, the traumatic visual reminder and the stigma...reinforces a sense of helplessness and the perception that the patient may not survive his or her disease,‘‘ Davis and his colleagues write.
, 百拇医药
``On the basis of the evidence presented here, clinical trials in cancer patients to assess the efficacy of this approach to prevent chemotherapy-induced alopecia may be warranted,‘‘ the authors conclude.
But despite the promising preliminary results, Davis said that the compounds used in the study must undergo further safety tests in animals before they can be tested in human clinical trials.
SOURCE: Science 2001;291:134-137., 百拇医药