蛋白酶激活受体-2与消化系统疾病的研究进展
蛋白酶激活受体-2;胃黏膜保护;胰腺炎;癌,刘建,李非,通讯作者:,Newdevelopmentsintherelationshipbetweenproteaseactivatedrecerptor-2andalimentarysystemdiseas
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刘建, 李非, 首都医科大学宣武医院普外科 北京市 100053
通讯作者: 刘建, 100053, 北京市宣武区长椿街45号, 首都医科大学宣武医院普外科. walterasdfg@163.com
电话: 010-83198835 传真: 010-83198731
收稿日期: 2007-01-15 接受日期: 2007-01-31
New developments in the relationship between protease activated recerptor-2 and alimentary system diseases
Jian Liu, Fei Li
Jian Liu, Fei Li, Department of general surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Correspondence to: Jian Liu, Department of general surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053,China. walterasdfg@163.com
Received:2007-01-15 Accepted:2007-01-31
Abstract
Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor, and its special molecule structure and activation way are similar to other protease-activated receptors. PAR-2 is widely distributed in alimentary system and series of effects are produced when it is activated by certain proteases. For example, PAR-2 exerts gastric mucosal cytoprotective effect, influences the secretion of digestive glands and movement of gastrointestinal tract, participates in the development of pancreatitis, and associates closely with malignant tumors in alimentary system. More and more researches are now focusing on the relationship between PAR-2 and alimentary system diseases.
Key Words: Protease activated recerptor-2; Gastric mucosal cytoprotective effect; Pancreatitis; Cancer
Liu J, Li F. New developments in the relationship between protease activated recerptor-2 and alimentary system diseases. Shijie Huaren Xiaohua Zazhi 2007;15(9):986-990
摘要
蛋白酶激活受体-2(protease activated receptor-2, PAR-2)属于G蛋白耦联受体, 具有蛋白酶受体家族较特异的分子结构与激活方式, 广泛分布于胃肠道, 可被多种蛋白酶激活, 产生多种生物学效应, 包括影响多种消化腺的分泌, 具有胃黏膜保护作用, 影响胃肠道运动, 参与胰腺炎的发生、发展, 与消化道恶性肿瘤密切相关. PAR-2与消化系统疾病的关系正成为当前研究的一个热点.
关键词: 蛋白酶激活受体-2; 胃黏膜保护; 胰腺炎; 癌
刘建, 李非. 蛋白酶激活受体-2与消化系统疾病的研究进展 ......
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