胃癌细胞增殖相关基因研究进展
胃癌;细胞增殖;基因;研究进展,李春杰,魏品康,通讯作者:,Researchprogressongeneexpressioncorrelatedwithgastriccancercellproliferation,Chun-JieLi,Pin-KangWei
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李春杰, 魏品康, 中国人民解放军第二军医大学长征医院中医科 上海市 200003
通讯作者: 魏品康, 200003, 上海市, 中国人民解放军第二军医大学长征医院中医科. czzyk@smmu.edu.cn
电话: 021-63610109-73408
收稿日期: 2007-01-15 接受日期: 2007-02-07
Research progress on gene expression correlated with gastric cancer cell proliferation
Chun-Jie Li, Pin-Kang Wei
Chun-Jie Li, Pin-Kang Wei,Department of Traditional Chinese Medicine, Changzheng Hospital of the Second Military Medical University, Shanghai 200003, China
Correspondence to:Pin-Kang Wei, Department of Traditional Chinese Medicine, Changzheng Hospital of the Second Military Medical University, Shanghai 200003, China. czzyk@smmu.edu.cn
Received: 2007-01-15 Accepted:2007-02-07
Abstract
Malignant tumor is difficult to be treated and has a poor prognosis due to its easy recurrence and metastasis, and the transfer and proliferation of tumor cells are closely related to cell proliferation activity. Therefore, the sticking point in the treatment of malignant tumor is to inhibit the proliferation of tumor cells. The article focuses on the aberrant expression and significances of proto-oncogenes, tumor suppressor genes and genes associated with the proliferation process of gastric cells such as telomerase, transcription factor and cyclooxygenase, etc. These genes, alone or synergically, participate in gastric cancer cell proliferation, resulting in an uncontrolled growth characterized by over-proliferation of decreased apoptosis of gastric cancer cells.
Key Words: Gastric cancer; Cells proliferation; Gene; Progression
Li CJ, Wei PK. Research progress on gene expression correlated with gastric cancer cell proliferation. Shijie Huaren Xiaohua Zazhi 2007;15(9):975-979
摘要
恶性肿瘤治疗困难和预后不良的主要原因, 就在于其易复发转移, 而恶性肿瘤细胞转移扩散与其细胞增殖活性密切相关. 因此抑制肿瘤细胞的恶性增殖, 是治疗恶性肿瘤的关键所在. 本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子、环氧化酶等基因以及参与细胞周期调控的原癌基因、抑癌基因的异常表达及临床意义, 这些基因或单独作用, 或相互协同, 参与胃癌细胞的增殖, 使肿瘤细胞生长以增殖过多、凋亡过少的失控性生长为特征 ......
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