幽门螺杆菌临床分离株耐药特点分析
幽门螺杆菌;抗生素;耐药,杨行堂,张俊杰,张旖晴,余远怀,陈锡美,王志荣,通讯作者:,CharacteristicsofantibioticresistanceofHelicobacterpyloristrainisolatedfrompatients,Xi
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杨行堂, 张俊杰, 张旖晴, 余远怀, 陈锡美, 王志荣, 同济大学附属同济医院消化科, 同济大学消化疾病研究所 上海市 200065
上海市科委科技发展基金项目, No. 044119647
通讯作者: 王志荣, 200065, 上海市新村路389号, 同济大学附属同济医院消化内科, 同济大学消化疾病研究所.
wzr62@yahoo.com.cn
电话: 021-56050408
收稿日期: 2007-01-02 接受日期: 2007-01-20
Characteristics of antibiotic resistance of Helicobacter pylori strain isolated from patients
Xing-Tang Yang, Jun-Jie Zhang, Yi-Qing Zhang, Yuan-Huai Yu, Xi-Mei Chen, Zhi-Rong Wang
Xing-Tang Yang, Jun-Jie Zhang, Yi-Qing Zhang, Yuan-Huai Yu, Xi-Mei Chen, Zhi-Rong Wang,Department of Gastroenterology, Tongji Hospital of Tongji University; Institute of Digestive Diseases, Tongji University, Shanghai 200065, China
Supported byShanghai Foundation for the Development of Science and Technology, No. 044119647
Correspondence to:Zhi-Rong Wang, Department of Gastroenterology, Tongji Hospital of Tongji University; Institute of Digestive Diseases, Tongji University, 389 Xincun Road, Shanghai 200065, China. wzr62@yahoo.com.cn
Received: 2007-01-02 Accepted:2007-01-20
Abstract
AIM: To analyze the resistance of clinical isolated H pylori strain to common antibiotics.
METHODS: H pylori strains were obtained by inoculating the specimens of 61 patients in the selective media for 96 hours at 37°C under microaerophilic conditions. Kirby-Bauer test was performed to detect the drug sensitivity of the 61 isolated H pylori strains to metronidazole, clarithromycin, amoxicillin and furazolidone.
RESULTS: The antibiotic resistant rates of H pylori strains to metronidazole, clarithromycin, amoxicillin and furazolidone were 54.1%, 37.7%, 41.0% and 45.9%, respectively, and there were no significant difference among them (P > 0.05). The resistance H pylori strains to metronidazole was related to the sex of patients (P = 0.037), and the resistance of H pylori strains to metronidazole, clarithromycin and amoxicillin was closely related to the history of antibiotic usage (P = 0 ......
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