幽门螺杆菌与胃黏膜bFGF, FGFR-2表达的关系及意义
幽门螺杆菌;碱性成纤维细胞生长因子;成纤维细胞生长因子受体-2;胃黏膜;癌变;免疫组织化学,幽门螺杆菌与胃黏膜bFGF,FGFR-2表达的关系及意义,李信,姜海行,雷琳,覃山羽,陈罡,李信,通讯作者:,CorrelationsofHelicobacterpyloriinfectionwi
 |
| 第3页 |
 |
| 第1页 |
参见附件(1146KB，6页)。
李信, 姜海行, 雷琳, 覃山羽, 广西医科大学第一附属医院消化内科 广西壮族自治区南宁市 530021
陈罡, 广西医科大学病理学教研室 广西壮族自治区南宁市 530021
李信, 硕士研究生, 主要从事幽门螺杆菌及胃癌发病机制的研究.
通讯作者: 姜海行, 530021, 广西壮族自治区南宁市双拥路22号, 广西医科大学第一附属医院消化内科. jihaxi@263.net
电话: 0771-5356501 传真: 0771-5354506
收稿日期: 2006-09-11 接受日期: 2007-01-04
Correlations of Helicobacter pylori infection with the expression of basic fibroblast growth factor and fibroblast growth factor receptor-2 in gastric mucosa and their significances
Xin Li, Hai-Xing Jiang, Gang Chen, Lin Lei, Shan-Yu Qin
Xin Li, Hai-Xing Jiang, Lin Lei, Shan-Yu Qin,Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 53002l, Guangxi Zhuang Autonomous Region, China
Gang Chen,Department of Pathology, Guangxi Medical University, Nanning 53002l, Guangxi Zhuang Autonomous Region, China
Correspondence to:Dr. Hai-Xing Jiang, Department of Gastroenterology, the First affiliated Hospital of Guangxi Medical University, Nanning 53002l, Guangxi Zhuang Autonomous Region, China. jihaxi@263.net
Received:2006-09-11 Accepted:2007-01-04
Abstract
AIM: To study the expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-2 (FGFR-2) in gastric mucosal epithelia with H pylori infection and their significances in the carcinogenesis of stomach cancer.
METHODS: A total of 30 patients with chronic superficial gastritis (CGS), 29 with intestinal metaplasia (IM), 31 with dysplasia (Dys) and 55 with gastric cancer (GC) were included in this study. The expression of bFGF and FGFR-2 were assessed by immunohistochemistry (SP method). Rapid urease test and histological examination with Warthin-Starry were used to determine the status of H pylori infection.
RESULTS: The expression of bFGF and FGFR-2 in CSG patients were significantly lower than those in the other patients (IM: χ2 = 4 ......
您现在查看是摘要介绍页，详见PDF附件(1146KB，6页)。