手术联合腹腔热化疗及免疫疗法治疗腹膜恶性间皮瘤11例
腹膜肿瘤;间皮瘤;诊断;联合疗法,黄晓辉,陈凛,李荣,通讯作者:,Treatmentofmalignantperitonealmesotheliomabyoperationcombinedwithintraperitonealhyperthe
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黄晓辉, 陈凛, 李荣, 中国人民解放军总医院普通外科 北京市 100853
通讯作者: 黄晓辉, 100853, 北京市海淀区复兴路28号, 中国人民解放军总医院普通外科. huangxhhh@sina.com
电话: 010-66937217
收稿日期: 2006-12-29 接受日期: 2007-01-27
Treatment of malignant peritoneal mesothelioma by operation combined with intraperitoneal hyperthermic perfusion chemotherapy and immunotherapy: an analysis of 11 cases
Xiao-Hui Huang, Lin Chen, Rong Li
Xiao-Hui Huang, Lin Chen, Rong Li,Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China
Correspondence to:Xiao-Hui Huang, Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Haidian District, Beijing 100853, China. huangxhhh@sina.com
Received:2006-12-29 Accepted:2007-01-27
Abstract
AIM: To discuss the efficacy of surgical treatment combined with intraperitoneal hyperthermic perfusion (IPHP) chemotherapy or immunotherapy for malignant peritoneal mesothelioma (MPM).
METHODS: Seventeen MPM patients were divided 3 groups. The former two groups (n = 11, n = 4) were treated with operation plus IPHP chemotherapy or immunotherapy and systematic chemotherapy, respectively, while the latter group (n = 2) received no treatment. The clinical data of the 17 cases were analyzed retrospectively. All the patients were followed up to observe the survival time.
RESULTS: All the patients, including 3 cases of small cell type, 5 cases of epithelial type, 4 cases of diffuse infiltration type and 6 unclassified cases, were diagnosed by pathological examination. The follow-up time was 5 to 67 months, and the medium survival time was 35 months. The survival time was 35.5 months in the combined treatment group, 11.3 months in the systematic chemotherapy group, and 4.5 months in the untreated group. The survival time was longer in the former one group than that in the latter two.
CONCLUSION: The diagnosis of MPM mainly depends on hydroperitoneal cytology, exploratory laparotomy and laparoscopy biopsy ......
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