血管紧张素II对肝星状细胞迁移和增殖的影响
血管紧张素Ⅱ;肝星状细胞;细胞迁移;增殖;MTT法,杨玲,侯晓华,胡胜军,徐敏,朱锐,朱清静,通讯作者:,EffectofangiotensinIIontheproliferationandmigrationofhepaticstellatecel
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杨玲, 侯晓华, 胡胜军, 徐敏, 朱锐, 华中科技大学同济医学院附属协和医院消化内科 湖北省武汉市 430022
朱清静, 湖北省中医院肝病中心 湖北省武汉市 430061
国家自然科学基金青年基金资助项目, No. 30500658
中国博士后科学基金资助项目, No. 2004035198
湖北省自然科学基金资助项目, No. 2004ABA236
通讯作者: 侯晓华, 430022, 湖北省武汉市, 华中科技大学同济医学院附属协和医院消化内科. houxh@public.wh.hb.cn
电话: 027-85726930
收稿日期: 2006-12-25 接受日期: 2007-01-20
Effect of angiotensin II on the proliferation and migration of hepatic stellate cells
Ling Yang, Qing-Jing Zhu, Xiao-Hua Hou, Sheng-Jun Hu, Min Xu, Rui Zhu
Ling Yang, Xiao-Hua Hou, Sheng-Jun Hu, Min Xu, Rui Zhu,Department of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Qing-Jing Zhu,Center of Liver Diseases, Hubei Hospital of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China
Supported byNational Natural Science Foundation (Youth Foundation) of China, No. 30500658, the Postdoctoral Science Foundation of China, No. 2004035198, and the Natural Science Foundation of Hubei Province, No. 2004ABA236
Correspondence to:Xiao-Hua Hou, Department of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. houxh@public.wh.hb.cn
Received:2006-12-25 Accepted:2007-01-20
Abstract
AIM: To explore the changes of the proliferation and migration ability of hepatic stellate cells (HSCs) induced by angiotensin Ⅱ (ANGⅡ).
METHODS: HSCs were incubated in vitro. The proliferation and migration ability of HSCs induced by ANGⅡ at different concentration were observed with MTT assay and Transwell chamber assay, respectively.
RESULTS: The proliferation of HSCs was significantly increased when ANGⅡ was used at the concentrations of 1, 2, 4, 8 and 10 μmol/L in comparison with that in the control cells (F = 2 ......
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