清热化瘀汤对老年胃食管反流病患者血清超氧化物歧化酶及脂质过氧化物的影响
胃食管反流病;清热化瘀汤;血清超氧化物歧化酶;脂质过氧化物,余国英,钟森,徐剑刚,李敬会,李德梅,余武,通讯作者:,EffectofQingreHuayudecoctiononthecontentsofsuperoxided
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余国英, 钟森, 徐剑刚, 李敬会, 李德梅, 余武, 郧阳医学院附属人民医院 湖北省十堰市 442000
通讯作者: 余国英, 442000, 湖北省十堰市, 郧阳医学院附属人民医院. yugy9888@163.com
电话: 0719-8637558 传真: 0719-8637558
收稿日期: 2006-09-28 接受日期: 2007-01-10
Effect of Qingre Huayu decoction on the contents of superoxide dismutase and lipid peroxide in old patients with gastroesophageal reflux disease
Guo-Ying Yu, Sen Zhong, Jian-Gang Xu, Jing-Hui Li, De-Mei Li, Wu Yu
Guo-Ying Yu, Sen Zhong, Jian-Gang Xu, Jing-Hui Li, De-Mei Li, Wu Yu,People’s Hospital Affiliated to Yunyang Medicine College, Shiyan 442000, Hubei Province, China
Correspondence to:Guo-Ying Yu, People’s Hospital Affiliated to Yunyang Medicine College, Shiyan 442000, Hubei Province, China. yugy9888@163.com
Received:2006-09-28 Accepted:2007-01-10
Abstract
AIM: To observe the effect of Qingre Huayu decoction (QHD) on the contents of superoxide dismutase (SOD) and lipid peroxide (LPO) in old patients with gastroesophageal reflux disease (GERD).
METHODS: A total of 160 cases of old patients with GERD were randomly divided into group A (n = 80) and B (n = 80), treated with QHD and Western medicine, respectively. The serum contents of SOD and LPO before and after treatment were detected by double antibody method and thiobarbituric acid reaction, respectively. The results were analyzed with t-test statistically.
RESULTS: After treatment, SOD content was increased in both groups, but got close to the normal level in group A. There was significant difference between group A and B (26.01 ± 2.56 kU/L vs 23.02 ± 2.54 kU/L, P < 0.05). However, the content of LPO was decreased in both groups after treatment, and there was also significant difference between group A and B (4.19 ± 0.52 mol/L vs 4.96 ± 1.13 mol/L, P < 0.05).
CONCLUSION: QHD has a favorable effect in the treatment of GERD by ameliorating the metabolic disorder of free radicals ......
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