Hedgehog-GLI信号通路在胰腺癌发生中的作用
胰腺癌;Hedgehog信号通路;GLI转录因子;基因治疗,郭杰芳,高军,李兆申,通讯作者:,RoleofHedgehog-GLIsignalingpathwayinthetumorigenesisofpancreaticcancer,J
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郭杰芳, 高军, 李兆申, 上海第二军医大学附属长海医院消化内科 上海市 200433
通讯作者: 李兆申, 200433, 上海市, 上海第二军医大学附属长海医院消化内科. zhsl@81890.net
电话: 021-25070552
收稿日期: 2006-10-31 接受日期: 2007-03-07
Role of Hedgehog-GLI signaling pathway in the tumorigenesis of pancreatic cancer
Jie-Fang Guo, Jun Gao, Zhao-Shen Li
Jie-Fang Guo, Jun Gao, Zhao-Shen Li,Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Correspondence to:Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China. zhsl@81890.net
Received:2006-10-31 Accepted:2007-03-07
Abstract
Recently, a series of researches have shown that uncontrolled activation of Hedgehog-GLI signaling pathway involved in the formation and maintenance of pancreatic cancer. GLI gene family, as the direct transcriptional mediator of target gene acting at the distal end of the Hh pathway, plays a crucial role in the process of tumorigenesis. In this review we focused on the role of Hedgehog-GLI signaling in the tumorigenesis of pancreatic cancer, the mechanisms that regulate the activity of oncogenic GLI, and the potential therapeutic strategies targeted on Hedgehog-GLI pathway.
Key Words: Pancreatic neoplasm; Hedgehog signaling pathway; GLI transcriptional factor; Gene therapy
Guo JF, Gao J, Li ZS. Role of Hedgehog-GLI signaling pathway in the tumourigenesis of pancreatic cancer. Shijie Huaren Xiaohua Zazhi 2007;15(10):1137-1140
摘要
近年来研究发现Hedgehog-GLI信号转导通路的异常激活参予胰腺癌的发生及恶性生物学特性的维持. GLI锌指转录因子作为该信号通路末端的靶基因直接调控子, 在这一过程中起着非常重要的作用. 本文就Hedgehog-GLI信号通路在胰腺癌发生中的作用、GLI转录活性的调控及致瘤作用、Hedgehog-GLI通路的靶向治疗价值等方面的研究进展作一综述.
关键词: 胰腺癌; Hedgehog信号通路; GLI转录因子; 基因治疗
郭杰芳, 高军, 李兆申. Hedgehog-GLI信号通路在胰腺癌发生中的作用. 世界华人消化杂志 2007;15(10):1137-1140
0 引言
在胚胎发生过程中, Hedgehog-GLI(Hh-GLI)信号转导通路参予调控胰腺的正常发育, 而在正常的成熟胰腺组织中无表达或仅轻度表达[1] ......
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