食管鳞癌中RECK和MMP-9蛋白表达的相关性及临床病理意义
基质金属蛋白酶-9;RECK蛋白;食管鳞癌;免疫组化;浸润;转移,李晟磊,赵秋民,刘宗文,赵志华,高冬玲,郑湘予,陈奎生,张云汉,李晟磊,通讯作者:,Correlationbetweentheproteinexpressionof
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李晟磊, 赵秋民, 刘宗文, 赵志华, 高冬玲, 郑湘予, 陈奎生, 张云汉, 郑州大学第一附属医院病理科, 河南省肿瘤病理重点实验室 河南省郑州市 450052
李晟磊, 2005级郑州大学医学院病理学博士生, 主要从事肿瘤病理的研究.
“十五”“211工程”重点学科建设项目, 教重办(2002)第2号
通讯作者: 张云汉, 450052, 河南省郑州市大学路40号, 郑州大学第一附属医院病理科, 河南省肿瘤病理重点实验室. yhzhang@zzu.edu.cn
电话: 0371-66658175 传真: 0371-66658175
收稿日期: 2007-01-30 接受日期: 2007-02-08
Correlation between the protein expression of reversion inducing cysteine rich protein with Kazal motifs and matrix matalloproteinase-9 in esophageal squamous cell carcinoma and its clinical pathological significance
Sheng-Lei Li, Qiu-Min Zhao, Zong-Wen Liu, Zhi-Hua Zhao, Dong-Ling Gao, Xiang-Yu Zheng, Kui-Sheng Chen, Yun-Han Zhang
Sheng-Lei Li, Qiu-Min Zhao, Zong-Wen Liu, Zhi-Hua Zhao, Dong-Ling Gao, Xiang-Yu Zheng, Kui-Sheng Chen, Yun-Han Zhang,Department of Pathology, the First Affiliated Hospital of Zhengzhou University; He’nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, He’nan Province, China
Supported bythe Tenth Five-Year Plan Research Foundation for the Key Constructional Project (211 Project) of Zhengzhou University, No. 2002-2
Correspondence to:Yun-Han Zhang, Department of Pathology, the First Affiliated Hospital of Zhengzhou University; He’nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, He’nan Province, China. yhzhang@zzu.edu.cn
Received:2007-01-30 Accepted:2007-02-08
Abstract
AIM: To investigate the expression of reversion inducing cysteine rich protein with Kazal motifs (RECK) and matrix metalloproteinase-9 (MMP-9) protein and their correlations with the occurrence, development, invasion and metasta-sis of esophageal squamous cell carcinoma.
METHODS: SP immunohistochemical method was used to detect the expression of RECK and MMP-9 protein in 62 cases of esophageal squamous cell carcinoma (EC), 31 cases of adjacent atypical hyperplasia (AH) and 62 cases of normal esophageal epithelium (NE) ......
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