大鼠急性胰腺炎时胰腺腺泡细胞凋亡及Bax, Caspase-8的表达
急性胰腺炎;腺泡细胞;凋亡;Bax;Caspase-8,大鼠急性胰腺炎时胰腺腺泡细胞凋亡及Bax,Caspase-8的表达,陈海龙,张桂信,宫爱霞,张利,陈海龙,通讯作者:,RoleofacinarcellapoptosisandexpressionofBaxandCaspase-8
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陈海龙, 张桂信, 大连医科大学附属第一医院普外科 辽宁省大连市 116011
宫爱霞, 大连医科大学附属第一医院消化内科 辽宁省大连市 116011
张利, 大连市中心医院中心实验室 辽宁省大连市 116033
陈海龙, 教授, 博士生导师, 主要从事胆胰疾病的基础与临床研究.
国家自然科学基金资助项目, No. 30271667
通讯作者: 陈海龙, 116011, 辽宁省大连市中山路222号, 大连医科大学附属第一医院普外科. hailongchen2006@126.com
电话: 0411-83600680 传真: 0411-83631284
收稿日期: 2007-01-21 接受日期: 2007-02-08
Role of acinar cell apoptosis and expression of Bax and Caspase-8 in rats with acute pancreatitis
Hai-Long Chen, Gui-Xin Zhang, Ai-Xia Gong, Li Zhang
Hai-Long Chen, Gui-Xin Zhang,Department of Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Ai-Xia Gong,Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Li Zhang,Center Laboratory, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China
Supported byNational Natural Science Foundation of China, No. 30271667
Correspondence to:Dr. Hai-Long Chen, Department of Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China. hailongchen2006@126.com
Received:2007-01-21 Accepted:2007-02-08
Abstract
AIM: To investigate the apoptosis of pancreatic acinar cells and the expression of apoptosis-regulated genes Bax and Caspase-8 in experi-mental acute pancreatitis and their correlations with the severity of the disease in rats.
METHODS: The models of acute edematous pancreatitis (AEP) and acute necrotizing pancreatitis (ANP) were established by retrograde injection of different concentrations of sodium deoxycholate into the common biliary and pancreatic duct, and then the rats were randomly divided into 3 groups (10 for each): sham operated group (control), AEP group (treated with 7.5 g/L sodium deoxycholate) and ANP group (treated with 15 g/L sodium deoxycholat) ......
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