胰腺腺泡细胞凋亡与急性胰腺炎及其治疗策略
急性胰腺炎;腺泡细胞;凋亡;治疗,张桂信,陈海龙,宫爱霞,张利,通讯作者:,Relationshipbetweenpancreaticacinarcellapoptosisandacutepancreatitisandthetherapeutic
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张桂信, 陈海龙, 大连医科大学附属第一医院普外科 辽宁省大连市 116011
宫爱霞, 大连医科大学附属第一医院消化内科 辽宁省大连市 116011
张利, 大连市中心医院中心实验室 辽宁省大连市 116033
国家自然科学基金资助项目, No. 30271667
通讯作者: 张桂信, 116023, 辽宁省大连市中山路465号, 大连医科大学研究生院. guixindl@yahoo.com.cn
电话: 0411-84721847 传真: 0411-83631284
收稿日期: 2007-01-24 接受日期: 2007-02-08
Relationship between pancreatic acinar cell apoptosis and acute pancreatitis and the therapeutic strategy for acute pancreatitis
Gui-Xin Zhang, Hai-Long Chen, Ai-Xia Gong, Li Zhang
Gui-Xin Zhang, Hai-Long Chen,Department of Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Ai-Xia Gong,Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Li Zhang,Center Laboratory, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China
Supported byNational Natural Science Foundation of China, No. 30271667
Correspondence to:Gui-Xin Zhang, Department of Graduate School, Dalian Medical University, Dalian 116023, Liaoning Province, China. guixindl@yahoo.com.cn
Received:2007-01-24 Accepted:2007-02-08
Abstract
Being a kind of automatic and gene-controlled cell death, cell apoptosis involves complicated regulatory mechanism and stimulates no inflammation, which is essentially different from necrosis. Many researches proved that the apoptosis of pancreatic acinal cells, which might be a protective reaction, had been observed both in experimental and clinical acute pancreatitis, and it had shown an inverse correlation with the severity of diseases. The purpose of this article is to summarize the advances in the mechanism of pancreatic acinar cell apoptosis during acute pancreatitis in recent years, and to expound the therapeutic approaches in the treatment of acute pancreatitis.
Key Words: Acute pancreatitis; Acinar cell; Apoptosis ......
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