SCID-hu小鼠在HBV感染研究中的应用
乙型肝炎病毒;SCID-hu小鼠;嵌合模型,赵琪,吴超,通讯作者:,ApplicationofSCID-humicemodelintheresearchofhepatitisBvirusinfection,QiZhao,ChaoWu,Suppo
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赵琪, 吴超, 南京大学医学院附属鼓楼医院感染科 江苏省南京市 210008
卫生部科研项目资助课题, No. 06-250
通讯作者: 吴超, 210008, 江苏省南京市, 南京大学医学院附属鼓楼医院感染科. wuchao@jlonline.com
电话: 025-83319552
收稿日期: 2007-01-19 接受日期: 2007-02-13
Application of SCID-hu mice model in the research of hepatitis B virus infection
Qi Zhao, Chao Wu
Qi Zhao, Chao Wu,Department of Infectious Diseases, Drum Tower Hospital Affiliated to Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
Supported bythe Scientific Research Program of Ministry of Public Health, No. 06-250
Correspondence to:Chao Wu, Department of Infectious Diseases, Drum Tower Hospital Affiliated to Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China. wuchao@jlonline.com
Received:2007-01-19 Accepted:2007-02-13
Abstract
Owing to the specific hepatotropic property, the process of hepatitis B virus (HBV) infection is not able to be repeated in other animal models. As a kind of animals with congenital immunodeficiency of T and B lymphocytes, SCID mice contribute a lot for the study of xenogeneic graft. Following the appearance of SCID-hu mouse models, scientists established the human-mouse chimeric model through transplantations of human hepatocytes and peripheral blood lymphocytes. This model was infected with HBV to investigate the pathogenesis of hepatitis B. The chimeric model simulates the process of HBV infection in human bodies, so the study based on this model is credible. In this article, we reviewed the advances in the applications of SCID-hu mice model in the research of HBV infection.
Key Words: Hepatitis B virus; SCID-hu mouse model; Chimeric model
Zhao Q, Wu C. Application of SCID-hu mice model in the research of hepatitis B virus infection. Shijie Huaren Xiaohua Zazhi 2007;15(10):1110-1114
摘要
乙型肝炎病毒由于其特殊的嗜肝性, 不易在其他动物模型重现其感染过程. SCID小鼠作为一种先天性T, B细胞双重缺陷动物, 为异种移植研究提供了极大的帮助 ......
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