恩替卡韦对慢性乙型肝炎患者树突状细胞功能的体外影响
慢性乙型肝炎;树突状细胞;恩替卡韦;细胞表型;混合淋巴细胞反应,卢高峰,唐芙爱,郑鹏远,马军,白经修,通讯作者:,Invitroeffectofentecavironthefunctionofdendriticcellsderivedfrom
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卢高峰, 唐芙爱, 郑鹏远, 马军, 白经修, 郑州大学第二附属医院消化科 河南省郑州市 450014
河南省卫生厅医学创新人才工程项目, No. 2004-47
通讯作者: 唐芙爱, 450014, 河南省郑州市经八路2号, 郑州大学第二附属医院消化科. lugaofeng@zzu.edu.cn
电话: 0371-65036928
收稿日期: 2007-03-14 接受日期: 2007-04-13
In vitro effect of entecavir on the function of dendritic cells derived from chronic hepatitis B patients
Gao-Feng Lu, Fu-Ai Tang, Peng-Yuan Zheng, Jun Ma, Jing-Xiu Bai
Gao-Feng Lu, Fu-Ai Tang, Peng-Yuan Zheng, Jun Ma, Jing-Xiu Bai,Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, He’nan Province, China
Supported bythe Innovation Talent Project from Health Department of He’nan Province, No. 2004-47
Correspondence to:Fu-Ai Tang, Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, He’nan Province, China. lugaofeng@zzu.edu.cn
Received:2007-03-14 Accepted:2007-04-13
Abstract
AIM: To investigate the effect of entecavir (ETV) on the function of dendritic cells (DC) derived from patients with chronic hepatitis B (CHB)in vitro.
METHODS: Peripheral blood mononuclear cells were isolated from CHB patients and healthy controls. After proliferation under induction, the cells were cultured by routine method. Then ETV was added to co-incubate with the cells on the 4th day. On day 8, DC were collected for the detection of phenotypes and mixed lymphocytic reactions.
RESULTS: After 8 days of cultivation, the differentiation of DC in the healthy controls was better than that in ETV-treated group, while ETV-treated group had a better differentiation than CHB group. In comparison with those in the healthy controls, the levels of CD1a (35.73 ± 3.12 vs 62.31 ± 5.22), CD80 (28.19 ± 1.64 vs 45.38 ± 3.10), CD83 (22.24 ± 2.14 vs 40.63 ± 7.21) and HLA-DR (36.74 ± 0.98 vs 56.05 ± 3.89) expression were significantly decreased in CHB group (all P < 0 ......
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