PTEN、P16表达与原发性胆囊癌病理生物学行为及预后的关系
胆囊肿瘤;PTEN蛋白;P16蛋白;免疫组织化学,许元鸿,欧阳兵,于国志,郭仁宣,郭克建,通讯作者:,SignificanceofPTENandP16proteinexpressioninprimarygallbladdercarc
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许元鸿, 欧阳兵, 于国志, 郭仁宣, 郭克建, 中国医科大学附属第一医院普通外科 辽宁省沈阳市 110001
通讯作者: 许元鸿, 110001, 辽宁省沈阳市, 中国医科大学附属第一医院普通外科. yuanhongxu@hotmail.com
收稿日期: 2007-02-12 接受日期: 2007-03-06
Significance of PTEN and P16 protein expression in primary gallbladder carcinoma
Yuan-Hong Xu, Bing Ou-Yang, Guo-Zhi Yu, Ren-Xuan Guo, Ke-Jian Guo
Yuan-Hong Xu, Bing OU-Yang, Guo-Zhi Yu, Ren-Xuan Guo, Ke-Jian Guo,Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to:Yuan-Hong Xu, Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yuanhongxu@hotmail.com
Received:2007-02-12 Accepted:2007-03-06
Abstract
AIM: To investigate the expression of PTEN and P16 protein expression as well as their correlations with the pathobiological behaviors and prognosis of PGC.
METHODS: The protein expression of PTEN and P16 were observed in 56 cases of PGC and 26 cases of gallbladder benign lesions were observed by immunohistochemistry (CAS method).
RESULTS: The positive rates of PTEN and P16 expression in PGC were 46.4% and 42.9%, respectively, significantly lower than those in gallbladder benign lesions (92.3%, 76.9%; P < 0.05). PTEN and P16 expression were associated with the invasion, metastasis and prognosis (P < 0 ......
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