急性胰腺炎与氧化应激
急性胰腺炎;氧化应激,王艳红,冯志杰,郝晓,通讯作者:,Relationshipbetweenacutepancreatitisandoxidativestress,Yan-HongWang,Zhi-JieFeng,XiaoHao,Correspondenceto
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王艳红, 冯志杰, 郝晓, 河北医科大学第二医院消化内科 河北省石家庄市 050000
通讯作者: 冯志杰, 050000, 河北省石家庄市, 河北医科大学第二医院消化内科. zhijiefeng2005@126.com
电话: 0311-87222951
收稿日期: 2007-01-15 接受日期: 2007-02-08
Relationship between acute pancreatitis and oxidative stress
Yan-Hong Wang, Zhi-Jie Feng, Xiao Hao
Yan-Hong Wang, Zhi-Jie Feng, Xiao Hao,Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Correspondence to:Zhi-Jie Feng, Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiezhuang 050000, Hebei Province, China. zhijiafeng2005@126.com
Received:2007-01-15 Accepted:2007-02-08
Abstract
Under the imbalance between generation of reactive oxygen species and inadequate antioxidant defense systems, oxidative stress can cause cell damage either directly or indirectly through altering signaling pathways. It is the etiopathogenisis and also the consequence of many diseases. Oxidative injury plays an important role not only in the pathogenesis of acute pancreatitis (AP) but also in pancreatitis-induced damages of other organs such as heart, liver, lung, kidney, alimentary canal and so on. Oxidative stress can produce a higher level of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which induce inflammatory reaction and microcirculation disturbance, and cell necrosis or apoptosis, leading to pancreatic inflammation and multiple organ dysfunction syndromes. The antioxidants can decrease the production of oxygen free radicals (or directly scavenge them), protect the antioxidant enzyme activity, reinforce the antioxidative capacity of bodies, and consequently play an obvious therapeutic effect on AP.
Key Words: Acute pancreatitis, Oxidative stress
Wang YH, Feng ZJ, Hao X. Relationship between acute pancreatitis and oxidative stress. Shijie Huaren Xiaohua Zazhi 2007;15(11):1266-1272 ......
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