抑癌基因WWOX在肝外胆管癌中的表达
肝外胆管癌;WWOX;实时RT-PCR;免疫组织化学,顾军,王梅,王雅杰,李咏梅,袁杨,薛春燕,通讯作者:,ExpressionofWWdomain-containingoxidoreductasegeneinpatientswithextrahepa
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顾军, 中国人民解放军第123医院肿瘤科 安徽省蚌埠市 233015
王梅, 王雅杰, 李咏梅, 袁杨, 薛春燕, 第二军医大学附属长海医院肿瘤科 上海市 200433
上海市科委自然科学基金资助项目, No. 04ZR14003
通讯作者: 王雅杰, 200433, 上海市第二军医大学附属长海医院肿瘤科. yajiewa@yahoo.com
电话: 0552-4973709 传真: 0552-4973709
收稿日期: 2006-10-17 接受日期: 2007-02-08
Expression of WW domain-containing oxidoreductase gene in patients with extrahepatic cholangiocarcinoma
Jun Gu, Mei Wang, Ya-Jie Wang, Yong-Mei Li, Yang Yuan, Chun-Yan Xue
Jun Gu,Department of Oncology, the 123rd Hospital of Chinese PLA, Bengbu 233015, Anhui Province, China
Mei Wang, Ya-Jie Wang, Yong-Mei Li, Yang Yuan, Chun-Yan Xue,Department of Oncology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China
Supported bythe Natural Science Research Programs of Science and Technology Commission of Shanghai Municipality, No. 04ZR14003
Correspondence to:Ya-Jie Wang, Department of Oncology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China. yajiewa@yahoo.com
Received:2006-10-17 Accepted:2007-02-08
Abstract
AIM: To determine the expression of WW domain-containing oxidoreductase (WWOX) messenger RNA (mRNA) and protein, and evaluate its clinicopathological significance in human extrahepatic cholangiocacinoma (ECC).
METHODS: Real-time reverse transcription-polymerase chain reaction and immunohistochemistry (UIP method) were used to detect the expression of WWOX mRNA and protein respectively in 21 ECC patients and 5 cases of normal bile duct tissues. The results were comparatively analyzed with the clinicopathological characteristics.
RESULTS: The expression of WWOX mRNA was significantly lower in ECC than that in normal bile duct tissues (8.936 × 10-7 ± 3.253 × 10-7 vs 1.079 × 10-6 ± 1.735 × 10-7,P < 0 ......
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