壳寡糖及其衍生物对糖尿病大鼠糖耐量及肠道微生态平衡的影响
壳寡糖;N-乙酰氨基单糖;糖尿病;大鼠;糖耐量;肠道微生态平衡,阎春玲,刘兵,刘万顺,阎春玲,通讯作者:,Effectofchitooligosaccharidesanditsderivativesonoralglucosetol
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阎春玲, 青岛大学医学院病理生理学专业 山东省青岛市 266071
刘兵, 刘万顺, 中国海洋大学海洋生命学院 山东省青岛市 266003
阎春玲, 2006年毕业于中国海洋大学, 海洋生物学博士, 主要从事海洋药物的研究.
国家十五科技攻关资助项目, No. 2001BA708B04-07
通讯作者: 阎春玲, 266071, 山东省青岛市宁夏路308号, 青岛大学医学院. ychl1@163.com
电话: 0532-83780035 传真: 0532-83780029
收稿日期: 2006-12-29 接受日期: 2007-01-20
Effect of chitooligosaccharides and its derivatives on oral glucose tolerance test and intestinal microecological balance in diabetic rats
Chun-Ling Yan, Bing Liu, Wan-Shun Liu
Chun-Ling Yan,Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266071, Shandong Province, China
Bing Liu, Wan-Shun Liu,College of Marine Life Sciences, Ocean University of China, Qingdao 266003, Shandong Province, China
Supported bythe National Key Technology Research and Development Program of China during the 10th Five-Year Plan Period, No. 2001BA708B04-07
Correspondence to:Dr. Chun-Ling Yan, Department of Pathophysiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, Shandong Province, China. ychl1@163.com
Received:2006-12-29 Accepted: 2007-01-20
Abstract
AIM: To investigate the effect of chitooligo-saccharides (COS) and N-acetylglucosamine (NAG) at different doses on oral glucose tole-rance test (OGTT) and intestinal microecological balance in rats with diabetes induced by streptozotocin (STZ).
METHODS: The diabetic model of Wistar rats was duplicated with STZ intraperitoneally (65 mg/kg, once). The rats were randomly divided into 9 groups: normal control, metformin, diabetes, COS-H, COS-M, COS-L, NAG-H, NAG-M, and NAG-L group. The rats in normal control and diabetes group were treated with distilled water (10 mL/kg), and those in metformin group were treated with metformin (200 mg/kg). The rats in COS-H, COS-M and COS-L group received high-, moderate- and low-dose COS treatment (250, 500, 1500 mg/kg), while those in NAG-H, NAG-M, and NAG-L group received high-, moderate- and low-dose NAG treatment (250, 500, 1500 mg/kg) ......
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