Toll样受体及其基因多态性与感染性疾病关系的研究进展
Toll样受体;基因多态性;感染性疾病,田地,田国保,崔建军,曾争,陆海英,通讯作者:,AdvancementoftherelationshipbetweengenepolymorphismsofToll-likereceptorsan
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田地, 田国保, 崔建军, 北京大学第一医院感染疾病科病毒研究室 北京市 100034
曾争, 陆海英, 北京大学第一医院感染疾病科 北京市 100034
国家自然科学基金资助项目, No. 30671855
美国国家癌症研究所(NCI)资助项目, N01-CO-12400
通讯作者: 曾争, 100034, 北京市, 北京大学第一医院感染疾病科. zeng@bjmu.edu.cn
电话: 010-66551799
收稿日期: 2007-01-17 接受日期: 2007-02-15
Advancement of the relationship between gene polymorphisms of Toll-like receptors and infectious diseases
Di Tian, Zheng Zeng, Hai-Ying Lu, Guo-Bao Tian, Jian-Jun Cui
Di Tian, Guo-Bao Tian, Jian-Jun Cui,Laboratory of Virology, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Zheng Zeng, Hai-Ying Lu,Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Supported byNational Natural Science Foundation of China, No. 30671855, and the National Cancer Institute of United States, N01-CO-12400
Correspondence to:Dr. Zheng Zeng, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China. zeng@bjmu.edu.cn
Received:2007-01-17 Accepted:2007-02-15
Abstract
Toll-like receptors (TLRs) were identified as transmembrane signal transduction proteins in recent years. As a group of pattern recognition receptors (PRRs), TLRs play important roles in the innate immunity by recognizing pathogen-associated molecular patterns (PAMPs). PAMPs trigger TLR signaling cascades, leading to the release of proinflammatory cytokines, and play critical roles in infectious diseases. Genetic polymorphisms affect the susceptibility of individuals to infectious diseases, and single nucleotide polymorphisms of TLR genes are associated with the inflammatory responses and susceptibility to infectious diseases. Most studies have indicated that the Asp299Gly and Thr399Ile of TLR4 as well as the Arg753Gln and Arg667Trp of TLR2 had close correlations with the pathogenesis of infectious diseases ......
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