肿瘤坏死因子α在大鼠脑外伤后急性胃黏膜病变中的作用
肿瘤坏死因子α;急性胃黏膜病变;脑外伤;大鼠,王娟,通讯作者:,Roleoftumornecrosisfactor-αinacutegastricmucosalinjuryinratsafteracutebraintrauma,JuanWa
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王娟, 中国人民解放军总医院消化科 北京市 100853
通讯作者: 王娟, 100853, 北京市海淀区复兴路28号, 中国人民解放军总医院消化科. wjlaqlss@sina.com
电话: 010-66937078 传真: 010-68154653
收稿日期: 2007-04-03 接受日期: 2007-04-13
Role of tumor necrosis factor-α in acute gastric mucosal injury in rats after acute brain trauma
Juan Wang
Juan Wang,Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China
Correspondence to:Juan Wang, Department of Gastroenterology, General Hospital of Chinese PLA, 28 Fuxing Road, Haidian District, Beijing 100853, China. wjlaqlss@sina.com
Received:2007-04-03 Accepted:2007-04-13
Abstract
AIM: To detect the content of tumor necrosis factor-α (TNF-α) in acute gastric mucosal injury in rats after acute brain trauma and explore its significance.
METHODS: Modified Allen’s method was used to induce the rat model of acute gastric mucosal injury after acute brain trauma. Meanwhile, the sham operation group was also designed. The content of TNF-α and ulcer index of gastric mucosa were determined at different time points (1, 3, 6, 24 h), and the pathological changes were also observed under light microscope.
RESULTS: The content of TNF-α in model group was significantly higher than that in control group at the 1st, 3rd, 6th and 24th hour (t = 16.45, P = 0.000; t = 5.252, P = 0.000; t = 9.099, P = 0.000; t = 12.028, P = 0.000). More severe injury occurred in model group and the ulcer index of gastric mucosa was markedly higher than that in control group at the 6th and 24th hour (t = 7.275, P = 0.000; t = 10.579, P = 0.000). TNF-α content was positively correlated with the ulcer index of gastric mucosa (r = 0.68, P = 0.004).
CONCLUSION: TNF-α plays a certen role in acute gastric mucosal injury after acute brain trauma.
Key Words: Tumor necrosis factor-α; Acute gastric mucosal injury; Brain trauma; Rat ......
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