肿瘤热疗的细胞分子作用机制及应用进展
肿瘤;热疗;机制;应用,彭远飞,郑民华,郑民华,通讯作者:,Cellularandmolecularmechanismandapplicationofhyperthermiafortumortherapy,Yuan-FeiPeng,Min-HuaZ
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彭远飞, 郑民华, 上海交通大学医学院附属瑞金医院普外科、上海市微创外科临床医学中心 上海市 200025
郑民华, 现任上海交通大学医学院瑞金临床医学院副院长, 瑞金医院副院长, 外科副主任, 主任医师, 上海市微创外科临床医学中心主任, 并兼任世界内镜外科联盟理事, 亚洲内镜与腹腔镜外科医师学会(ELSA)常务理事, 亚太疝学会创始委员, 中华医学会腹腔镜与内镜外科学组主任委员, 中国抗癌协会大肠癌专业委员会常委, 中国抗癌协会大肠癌专业委员会腹腔镜外科学组组长, 上海医学会循证医学学会委员, 上海市内镜手术质控中心专家组成员. 共发表论文100余篇, 5篇被SCI收录, 出版专著3本, 参编8本.
通讯作者: 郑民华, 200025, 上海市瑞金二路197号, 上海交通大学医学院附属瑞金医院普外科、上海市微创外科临床医学中心. zmhtiger@yeah.net电话: 021-64370045-664553
收稿日期: 2007-03-08 接受日期: 2007-03-31
Cellular and molecular mechanism and application of hyperthermia for tumor therapy
Yuan-Fei Peng, Min-Hua Zheng
Yuan-Fei Peng, Min-Hua Zheng,Department of General Surgery, Ruijin Hospital Affiliated to Medical College of Shanghai Jiao Tong University; Shanghai Minimally Invasive Surgery Center, Shanghai 200025, China
Correspondence to:Min-Hua Zheng, Department of General Surgery, Ruijin Hospital Affiliated to Medical College of Shanghai Jiao Tong University; Shanghai Minimally Invasive Surgery Center, 197 Ruijin Second Road, Shanghai 200025, China. zmhtiger@yeah.net
Received:2007-03-08 Accepted:2007-03-31
Abstract
Hyperthermia is effective in the treatment of neoplasm, but its mechanism remains unclear for a long time. In recent years, great advances were achieved on its mechanism. In vitro and in vivo studies show that heat-induced apoptosis plays a dominant role in mild and moderate hyperthermia while necrosis in serious one. Heat induces apoptosis through mitochondria or/and death receptor pathways, and oxidative stress, intracellular Ca2+ increase and some molecules such as p53 and Bax play important roles in this process. Based on this mechanism, new therapies have been investigated and developed, including hyperthermia combined with gene therapy, calcium- and oxidative stress-targeted therapy, or decreasing extracellular pH value, which may remarkably enhance the effect of hyperthermia ......
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