牛磺酸对大鼠移植胰腺缺血再灌注损伤的保护作用
牛磺酸;胰腺移植;缺血再灌注损伤;肿瘤坏死因子-α;白细胞介素-1b;免疫组织化学,张克忠,刘永锋,程颖,刘树荣,王凤山,石蕊,赵宁,张克忠,通讯作者:,Protectiveeffectoftaurineagainstischemiaandrep
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张克忠, 刘永锋, 程颖, 刘树荣, 王凤山, 石蕊, 赵宁, 中国医科大学附属第一医院普外一科暨器官移植科 辽宁省沈阳市 110001
张克忠, 在读博士, 研究方向为器官移植、肝胆外科.
通讯作者: 刘永锋, 110001, 辽宁省沈阳市南京北街155号, 中国医科大学附属第一医院普外一科暨器官移植科.
yfliu@mail.cum.edu.cn
电话: 024-23265284 传真: 024-23252007
收稿日期: 2007-02-10 接受日期: 2007-03-06
Protective effect of taurine against ischemia and reperfusion injury of transplanted pancreas in rats
Ke-Zhong Zhang, Yong-Feng Liu, Ying Cheng, Shu-Rong Liu, Feng-Shan Wang, Rui Shi, Ning Zhao
Ke-Zhong Zhang, Yong-Feng Liu, Ying Cheng, Shu-Rong Liu, Feng-Shan Wang, Rui Shi, Ning Zhao, Department of Surgery and Organ Transplant Unit, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to:Dr. Yong-Feng Liu, Department of Surgery and Organ Transplant Unit, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yfliu@mail.cum.edu.cn
Received:2007-02-10 Accepted:2007-03-06
Abstract
AIM: To investigate the protective effect of taurine (TAU) on the ischemia and reperfusion injury during pancreas transplantation and its mechanism in rats.
METHODS: Rat models of pancreatic-duodenal transplantation were used in this study. Thirty Wistar rats were randomly allocated into 3 groups (n = 10), including control group (CMU-1 preservation solution), experiment group A (CMU-1 + TAU 5 mmol/L) and experiment group B (CMU-1 + TAU 10 mmol/L) (The liquid CMU-1 is multi-organ preservation solution produced in our laboratory). Blood samples were collected 6 hours after reperfusion for examination of serum amylase level. Pancreatic tissues were collect for pathologic observation. The expression of tumor necrosis factor-α (TNF-α) and interleukin-1b (IL-1b) were determined by immunohistochemistry using integrated optical density (IOD).
RESULTS: In comparison with that in control group, the level of serum amylase was increased 6 hours after reperfusion in experiment group A and B (911 ......
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