非酒精性脂肪肝患者同型半胱氨酸浓度及叶酸与维生素B12浓度变化及相关性
非酒精性脂肪性肝病;同型半胱氨酸;叶酸;维生素B12;危险因素,非酒精性脂肪肝患者同型半胱氨酸浓度及叶酸与维生素B12浓度变化及相关性,杨慧君,李倩,崔玲,钱玉中,李文静,唐燕,通讯作者:,Researchontheplasmalevelsofhomocysteine,folateandvita
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杨慧君, 李倩, 崔玲, 钱玉中, 李文静, 唐燕, 石家庄市第一医院干部病房 河北省石家庄市 050011
河北省科技发展项目, No. 052761543
通讯作者: 杨慧君, 050011, 河北省石家庄市范西路36号, 石家庄市第一医院干部病房. yanghuijun79@126.com
电话: 0311-86919372
收稿日期: 2007- 03-01 接受日期: 2007-03-23
Research on the plasma levels of homocysteine, folate and vitamin B12 and their correlations in nonalcoholic fatty liver disease
Hui-Jun Yang, Qian Li, Ling Cui, Yu-Zhong Qian, Wen-Jing Li, Yan Tang
Hui-JunYang, Qian Li, Ling Cui, Yu-Zhong Qian, Wen-Jing Li, Yan Tang,Department for Cadre, the First Hospital of Shijiazhuang City, Shijiazhuang 050011, Hebei Province, China
Supported bythe Science and Technology Development Foundation of Hebei Province, No. 052761543
Correspondence to:Hui-Jun Yang, Department for Cadre, the First Hospital of Shijiazhuang City, Shijiazhuang 050011, Hebei Province, China. yanghuijun79@126.com China. yanghuijun79@126.com
Received:2007-3-1 Accepted:2007-3-23
Abstract
AIM: To explore the plasma levels of homocy-steine, folate and vitamin B12 as well as their correlations in nonalcoholic fatty liver disease (NAFLD).
METHODS: B-ultrasound examination was performed on 199 individuals, of which 67 cases were confirmed with NAFLD and 132 cases served as controls. The plasma levels of homocysteine, folate and vitamin B12 were tested and their correlations were analyzed.
RESULTS: The plasma level of homocysteine in NAFLD group was higher than that in normal group (18.64 ± 11.2 µmol/L vs 12.49 ± 6.4 µmol/L, P < 0.01), and an inverse linear correlation existed between the plasma levels of homocysteine and folate (r = -0.381,P < 0.01), either between the plasma levels of homocysteine and vitamin B12 (r = -0.561, P < 0.001).
CONCLUSION: The plasma level of homocysteine is enhanced in NAFLD patients, and hyperhomocysteinemia may be a new risk factor in NAFLD ......
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