白花蛇舌草总黄酮对肝癌的体内外抑制作用及对小鼠移植性肝癌H22细胞增殖周期、凋亡、免疫环境的影响
白花蛇舌草;总黄酮;肝癌;抑制作用;增殖周期;凋亡;免疫;肿瘤坏死因子-a;干扰素-g;MTT法,张硕,周三,杨志宏,刘占涛,岳旺,宋衍芹,倪同尚,张硕,通讯作者:,Inhibitory
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张硕, 周三, 杨志宏, 刘占涛, 岳旺, 青岛大学医学院药学系 山东省青岛市 266021
宋衍芹, 青岛市市立医院口腔科 山东省青岛市 266071
倪同尚, 青岛大学医学院解剖教研室 山东省青岛市 266021
张硕, 2005年成都中医药大学中药学博士, 主要从事天然药物药理研究和毒理评价.
通讯作者: 岳旺, 266021, 山东省青岛市登州路38号, 青岛大学医学院药学系. dr_zhangshuo@sina.com
电话: 0532-82991888
收稿日期: 2007-01-30 接受日期: 2007-02-13
Inhibitory effect of favonoids from Hedyotis diffusa willd. on hepatoma cells in vitro & vivo and its influence on transplanted H22 tumor cells’ proliferation cycle, apoptosis and immune circumstances in mice
Shuo Zhang, Yan-Qin Song, San Zhou, Zhi-Hong Yang, Zhan-Tao Liu, Tong-Shang Ni, Wang Yue
Shuo Zhang, San Zhou, Zhi-Hong Yang, Zhan-Tao Liu, Wang Yue,Department of Pharmacy, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Yan-Qin Song,Department of Stomatology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Tong-Shang Ni,Department of Anatomy, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Correspondence to:Wang Yue, Department of Pharmacy, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China. dr_zhangshuo@sina.com
Received:2007-01-30 Accepted:2007-02-13
Abstract
AIM: To investigate the inhibitory effect of favonoids from Hedyotis diffusa willd. (FHD) on human hepatoma cell line SMMC-7721 and BEL-7402 in vitro, the antitumor effect on transplanted H22 tumor cells in vivo and its influence on the proliferation cycle, apoptosis of tumor cells and immune circumstances.
METHODS: MTT assay was used to measure the inhibition of SMMC-7721 and BEL-7402 cells exposing to 0, 5, 10, 50 and 100 mg/L FHD for 24, 48 and 72 hours. Sixty Kunming mice were randomly and averagely divided into 6 groups. Except those in normal control group, the other mice received inoculation of H22 tumor cells, and then treated with normal saline, 5-fluorouracil (30 mg/kg), and FHD (25, 50, 100 mg/kg), respectively, for 10 days ......
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