大鼠肝卵圆细胞增殖模型肝脏的GJIC功能和意义
大鼠;肝卵圆细胞;缝隙连接蛋白;缝隙连接细胞间通讯;调控;免疫组化;逆转录-聚合酶链反应;免疫印迹;切开标记,染料示踪技术,李学东,傅华群,尚西亮,邢宏松,胡鹏,李少华,李学东,通讯作者:,Functionandsignificanceof
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李学东, 傅华群, 尚西亮, 邢宏松, 胡鹏, 南昌大学第二附属医院肝胆外科 江西省南昌市 330006
李少华, 黑龙江省鸡东中医院普外科 黑龙江省鸡西市158200
李学东, 医学博士, 主要从事缝隙连接蛋白对干细胞生物学效应的研究.
江西省自然科学基金项目, No. 0640112
江西省教育厅科技计划基金项目, No. 061033
江西省科技厅科研基金项目, No. 200680
江西省卫生厅中医药科研基金项目, No. 2005A30
昆明制药集团股份有限公司科研基金项目
通讯作者: 傅华群, 330006, 江西省南昌市, 南昌大学第二附属医院肝胆外科. ncdxfhq@yahoo.com.cn
电话: 0791-6259631
收稿日期: 2007-01-23 接受日期: 2007-02-08
Function and significance of gap junction intercellular communication in rat liver for hepatic oval cell proliferation in vivo
Xue-Dong Li, Hua-Qun Fu, Shao-Hua Li, Xi-Liang Shang, Hong-Song Xing, Peng Hu
Xue-Dong Li, Hua-Qun Fu, Xi-Liang Shang, Hong-Song Xing, Peng Hu,Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Shao-Hua Li,Department of General Surgery, Jidong Hospital of Traditional Chinese Medicine, Jixi 158200, Heilongjiang Province, China
Supported bythe Natural Science Foundation of Jiangxi Province, No. 0640112; the Scientific Research Project Foundation of Jiangxi Provincial Education Department, No. 061033; the Scientific Research Foundation of Jiangxi Provincial Science and Technology Department, No. 200680; the Scientific Research Foundation of Traditional Chinese Medicine of Jiangxi Provincial Health Department, No. 2005A30; the Scientific Research Foundation of Kunming Pharmaceutical Corporation.
Correspondence to:Hua-Qun Fu, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. ncdxfhq@yahoo.com.cn
Received:2007-01-23 Accepted:2007-02-08
Abstract
AIM: To study the expression of connexin 32 (CX32) and connexin 43 (CX43) and function of gap junction intercellular communication (GJIC) in rat liver during 2-acetylaminofluorene/partial hepatectomy (2AAF/PH) for hepatic oval cell (HOC) proliferation, and explore the potential mechanism of HOC proliferation in vivo ......
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