干细胞、肿瘤干细胞与肿瘤发生
干细胞;肿瘤干细胞;细胞分化;肿瘤发生;流式细胞仪,钱波,蔡寒青,冯洁,通讯作者:,Associationofstemcellsandcancerstemcellswithtumorigenesis,BoQian,Han-QingCai,JieFeng,Co
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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研究生院 北京市 100730
通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学科学院中国协和医科大学中日临床研究所. qianbo79@163.com
电话: 010-84206005 传真: 010-64206643
收稿日期: 2007-03-17 接受日期: 2007-04-25
Association of stem cells and cancer stem cells with tumorigenesis
Bo Qian, Han-Qing Cai, Jie Feng
Bo Qian, Han-Qing Cai, Jie Feng,Postgraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Correspondence to:Bo Qian, China-Japan Clinical Research Institute, Peking Union Medical College, Chinese Academy of Medical Sciences, 2 Yinghua East Street, Beijing 100029, China. qianbo79@163.com
Received:2007-03-17 Accepted:2007-04-25
Abstract
The research on cancer stem cells is a new hot spot in at present. The hypothesis indicates cancer stem cells, which were possibly the origin of the cancer, come from normal stem cells. For their special characters, normal stem cells can differentiate into tumor cells more easily than adult cells. Stem cells transform into malignant cancer stem cells possibly because of gene mutation, abnormal asymmetry and cell fusion. It is a main method to obtain cancer stem cells by flow cytometer using different protein markers and fluorescent probes. It is demonstrated that cancer stem cells are very powerful in self-renewal, proliferation, and differentiation. Targeting on cancer stem cells, early diagnosis for cancers might be achieved.
Key Words: Stem cell; Cancer stem cell; Cell differentiation; Tumorigenesis; Flow cytometer
Qian B, Cai HQ, Feng J. Association of stem cells and cancer stem cells with tumorigenesis. Shijie Huaren Xiaohua Zazhi 2007;15(13):1526-1531
摘要
肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则由正常干细胞恶变形成. 正常干细胞的特有性状, 使其较成体细胞更易成为肿瘤发生的靶细胞. 干细胞可能经基因突变、异常不对称分裂和细胞融合转化为肿瘤干细胞. 利用不同的蛋白标志物或荧光探针, 通过流式细胞仪分选是发现肿瘤干细胞的主要方法. 已证实的肿瘤干细胞皆具有强大的自我更新和增殖能力, 以及细胞分化潜能 ......
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