胃电刺激对大鼠海马胃扩张反应神经元及胃动素和nNOS表达的影响
胃电刺激;海马;胃动素;一氧化氮合酶;免疫荧光组织化学;放射免疫;大鼠,鹿勇,徐珞,孙向荣,魏晓芳,陆江,陈建德,鹿勇,通讯作者:,Effectsofgastricelectricalstimulationonhippo
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鹿勇, 徐珞, 孙向荣, 魏晓芳, 青岛大学医学院病理生理教研室 山东省青岛市 266021
陆江, 青岛市第五人民医院消化内科 山东省青岛市 266000
陈建德, 美国德克萨斯大学医学院
鹿勇, 青岛大学医学院病理生理教研室, 硕士研究生, 研究方向为胃肠疾病的神经内分泌调控.
国家自然科学基金资助项目, No. 30470642和No. 30670780
青岛市科技局资助项目, No. 05-1-JC-93
通讯作者: 徐珞, 266021, 山东省青岛市登州路38号, 青岛大学医学院病理生理教研室. xu.luo@163.com
电话: 0532-82991713 传真: 0532-83813986
收稿日期: 2007-01-30 接受日期: 2007-02-21
Effects of gastric electrical stimulation on hippocampus gastric distension responsive neurons and the expression of motilin and neuronal nitric oxide synthase in rats
Yong Lu, Luo Xu, Xiang-Rong Sun, Xiao-Fang Wei, Jiang Lu, Jian-De Chen
Yong Lu, Luo Xu, Xiang-Rong Sun, Xiao-Fang Wei,Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Jiang Lu,Qingdao Fifth People’s Hospital, Qingdao 266000, Shandong Province, China
Jian-De Chen,University of Texas Medical Branch, Galveston, TX, USA
Supported byNational Natural Science Foundation of China, No. 30470642 and 30670780, and the Fund from Qingdao Science and Technology Division, No. 05-1-JC-93
Correspondence to:Dr. Luo Xu, Department of Pathophysiology, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China. xu.luo@163.com
Received:2007-01-30 Accepted:2007-02-21
Abstract
AIM: To explore the effects of gastric electrical stimulation (GES) on gastric distension (GD) responsive neurons in rat hippocampus, and study the expression of neuronal nitric oxide synthase (nNOS) and motilin (MTL) in rat brain for exploring the central mechanism of GES.
METHODS: Fifty adult Wistar rats were used in this experiment. The effects of GES on GD responsive neurons in hippocampus CA1 area were observed by recording extracellular potentials of single neuron. GD responsive neurons were classified as GD-excitatory (GD-E) and GD-inhibitory (GD-I) neurons according to their responses to GD ......
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