温胃舒、养胃舒预防幽门螺杆菌培养上清液所致小鼠胃黏膜损伤
胃黏膜;细胞保护;幽门螺杆菌;温胃舒;养胃舒,牟方宏,杨桂彬,胡伏莲,牟方宏,通讯作者:,ProtectiveeffectsoftraditionalChinesemedicineWenweishuandYangweishuaga
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牟方宏, 杨桂彬, 北京大学航天临床医学院消化科 北京市 100049
胡伏莲, 北京大学第一医院消化科 北京市 100034
牟方宏, 北京大学航天临床医学院消化科副主任医师, 主要从事幽门螺杆菌与上胃肠道疾病的基础与临床研究.
通讯作者: 胡伏莲, 100034, 北京市西城区西什库大街8号, 北京大学第一医院消化科. hufl@263.net
电话: 010-66121882
收稿日期: 2007-01-05 接受日期: 2007-01-27
Protective effects of traditional Chinese medicine Wenweishu and Yangweishu against gastric mucosal lesions induced by Helicobacter pylori concentrated culture supernatant in mice
Fang-Hong Mu, Fu-Lian Hu, Gui-Bin Yang
Fang-Hong Mu, Gui-Bin Yang,Department of Gastroenterology, Clinical School of Aerospace Medicine, Beijing University, Beijing 100049, China
Fu-Lian Hu,Department of Gastroenterology, the First Hospital of Beijing University, Beijing 100034, China
Correspondence to:Fu-Lian Hu, Department of Gastroenterology, the First Hospital of Beijing University, 8 Xishiku Street, Xicheng District, Beijing 100034, China. hufl@263.net
Received:2007-01-05 Accepted:2007-01-27
Abstract
AIM: To evaluate the effect of traditional Chinese medicine Wenweishu and Yangweishu on gastric mucosal injury induced by H pylori concentrated culture supernatant (CCS) in BALB/c mice.
METHODS: Seventy-five BALB/c mice were divided into group A, B, C, D and E. The mice in group A and B were treated with normal saline, and those in group C, D and E were treated intragastrically with sucralfate, Wenweishu and Yangweishu, respectively, in advance. Then the mice in group A served as normal controls, and gastric mucosal lesions were induced by intragastric administration of H pylori CCS in the other four groups. The gastric mucosal changes were assessed by microscopic examination, quantitative histology and electron microscopy.
RESULTS: Histology and ultrastructure were remarkably damaged in group B, but they were obviously alleviated in group C, D and E. The epithelial damage scores (EDS) were 1 ......
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