半夏泻心汤抑制DMH/DSS诱导的结肠炎相关性结肠癌的发生
半夏泻心汤;结肠炎;结肠癌;1,2-二甲肼;右旋葡聚糖苷钠,冯娟,刘莉,李宇华,孙阳,张蓉,刘振国,王庆伟,梅其炳,冯娟,通讯作者:,PinelliaeDecoctionforPurgingStomach-Fireinhibitthei
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冯娟, 刘莉, 李宇华, 孙阳, 张蓉, 刘振国, 王庆伟, 梅其炳, 第四军医大学药学系药理教研室 陕西省西安市 710032
冯娟, 硕士, 主要从事中药药理方面的研究.
通讯作者: 梅其炳, 710032, 陕西省西安市, 第四军医大学药学系药理教研室. qbmei@fmmu.edu.cn
电话: 029-84774555
收稿日期: 2007-02-02 接受日期: 2007-03-06
Pinelliae Decoction for Purging Stomach-Fire inhibit the incidence of colitis-related colon cancer induced by 1, 2-dimethylhydrazine and dextran sodium sulfate
Juan Feng, Li Liu, Yu-Hua Li, Yang Sun, Rong Zhang, Zhen-Guo Liu, Qing-Wei Wang, Qi-Bing Mei
Juan Feng, Li Liu, Yu-Hua Li, Yang Sun, Rong Zhang, Zhen-Guo Liu, Qing-Wei Wang, Qi-Bing Mei, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Correspondence to: Qi-Bing Mei, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China. qbmei@fmmu.edu.cn
Received: 2007-02-02 Accepted: 2007-03-06
Abstract
AIM: To observe the inhibitory effects of Pinelliae Decoction for Purging Stomach-Fire (PDPSF) on the development from colitis to colon cancer.
METHODS: A total of 65 male ICR mice were randomly divided into normal group, model group and PDPSF groups with different doses. Except 10 mice in normal group, the other mice were given a single intraperitoneal injection of 1, 2-dimethylhydrazine (DMH) at the dose of 20 mg/kg body weight. One week after the injection, the animals were given 20 g/L dextran sodium sulfate (DSS) in drinking water for 7 consecutive days. Except the 20 mice in model group, 10 of the remaining survived 30 mice were administered orally with PDPSF at doses of 100, 200 and 400 mg/kg, respectively, once daily for 11 weeks. In the 20th week, all the mice were sacrificed, and the colon was removed, weighted and fixed with 40 g/L formalin for HE staining.
RESULTS: In the 20th week, rectal prolapse was investigated in 40% mice in model group, and the occurrence rate of carcinoma was 85% ......
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