维生素C和维生素E对小鼠化学性肝损伤的预防性保护作用
维生素C;维生素E;肝损伤;预防性保护,孙设宗,唐微,承江,孟新云,通讯作者:,ProtectiveeffectofvitaminCandEagainstchemicalliverinjuryinmice,She-ZongSun,Wei
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孙设宗, 唐微, 郧阳医学院生化与免疫学实验室 湖北省十堰市 442000
胡承江, 郧阳医学院病理学教研室 湖北省十堰市 442000
孟新云, 郧阳医学院医疗保键中心 湖北省十堰市 442000
郧阳医学院中青年基金项目, No. 2005ZQY02
通讯作者: 孙设宗, 442000, 湖北省十堰市人民南路30号, 郧阳医学院生化与免疫学实验室. sunshezhun@yahoo.com.cn
电话: 0719-8875324
收稿日期: 2006-07-20 接受日期: 2006-08-10
Protective effect of vitamin C and E against chemical liver injury in mice
She-Zong Sun, Wei Tang, Cheng-Jiang Hu, Xin-Yun Meng
She-Zong Sun, Wei Tang, Laboratory of Biochemistry and Immunity, Yunyang Medical College, Shiyan 442000, Hubei Province, China
Cheng-Jiang Hu, Department of Pathology, Yunyang Medical College, Shiyan 442000, Hubei Province, China
Xin-Yun Meng, Healthcare Department of Yunyang Medical College, Shiyan 442000, Hubei Province, China
Supported by the Middle-aged and Young Talent Project of Yunyang Medical College, No. 2005ZQY02
Correspondence to: She-Zong Sun, Laboratory of Biochemistry and Immunity, Yunyang Medical College, 30 Renmin South Road, Shiyan 442000, Hubei Province, China. sunshezhun@yahoo.com.cn
Received: 2006-07-20 Accepted: 2006-08-10
Abstract
AIM: To find out the protective effect of vitamin C (VC) and vitamin E (VE) against chemical liver injury caused by carbon tetrachloride (CCl4).
METHODS: A total of 60 Kunming rats were randomly divided into 5 groups: control group, model group, VC-treated group, VE-treated group, and VC plus VE group. After 10 days of treatment, 1.5 mL/L CCl4 were injected into all the mice except those in control group to induce liver injury. Finally, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and tissue contents of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) were examined. The morphological changes of liver tissues were observed under light microscope ......
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