蛇床子素对四氯化碳诱导小鼠脂质过氧化反应的影响
蛇床子素;四氯化碳;脂质过氧化,刘建新,周青,周俐,赵海燕,连其深,通讯作者:,InfluenceofOstholeonlipidperoxidationinducedbycarbontetrachlorideinmice,ian-XinLiu
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刘建新, 周青, 周俐, 赵海燕, 连其深, 赣南医学院药理学教研室 江西省赣州市 341000
国家自然科学基金资助项目, No. 30560172
江西省自然科学基金资助项目, No. 0640005
2005年江西省中医药科研计划, No. 2005A55
通讯作者: 刘建新, 341000, 江西省赣州市医学院路1号, 赣南医学院药理学教研室. jianxingliu@yahoo.com.cn
电话: 0797-8269773 传真: 0797-8269600
收稿日期: 2007-01-18 接受日期: 2007-02-13
Influence of Osthole on lipid peroxidation induced by carbon tetrachloride in mice
Jian-Xin Liu, Qing Zhou, Li Zhou, Hai-Yan Zhao, Qi-Shen Lian
Jian-Xin Liu, Qing Zhou, Li Zhou, Hai-Yan Zhao, Qi-Shen Lian, Department of Pharmacology, Gannan Medical College, Ganzhou 341000, Jiangxi Province, China
Supported by National Natural Science Foundation of China, No. 30560172, and Natural Science Foudation of Jiangxi Province, No. 0640005, and Jiangxi Province Administration of Tradition Chinese Medicine, No. 2005A55
Correspondence to: Jian-Xin Liu, Department of Pharmacology, Gannan Medical College, 1 Yixueyuan Road, Ganzhou 341000, Jiangxi Province, China. jianxingliu@yahoo.com.cn
Received: 2007-01-18 Accepted: 2007-02-13
Abstract
AIM: To study the anti-lipid peroxidation effect of Osthole during acute hepatic injury induced by carbon tetrachloride (CCl4) in mice.
METHODS: Forty Kunming mice were randomly and equally divided into normal control group, model group, Osthole-Ⅰ group (treated with 50 g/kg Osthole) and Osthole-Ⅱ group (treated with 100 g/kg Osthole). Except those in the normal control group, the mice in the other groups were intraperitoneally injected with 1 g/L CCl4 (peanut oil solution) ......
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