食管癌和环氧合酶-2关系的研究进展
食管癌;环氧合酶-2;肿瘤发生;预防;治疗,胡卫,沈志祥,通讯作者:,Advanceoftherelationshipbetweenesophagealcancerandcyclooxygenase-2,WeiHu,Correspondenceto
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胡卫, 武汉大学医院内科 湖北省武汉市 430072
沈志祥, 武汉大学人民医院内科 湖北省武汉市 430070
通讯作者: 胡卫, 430072, 湖北省武汉市, 武汉大学医院内科. wiwine@sina.com
电话: 027-68759740
收稿日期: 2007-03-17 接受日期: 2007-04-21
Advance of the relationship between esophageal cancer and cyclooxygenase-2
Wei Hu, Zhi-Xiang Shen
Wei Hu,Department of Internal Medicine, Hospital of Wuhan University, Wuhan 430072, Hubei Province, China
Zhi-Xiang Shen, Department of Internal Medicine, People’s Hospital of Wuhan University,Wuhan 430070, Hubei Province, China
Correspondence to:Wei Hu, Department of Internal Medicine, Hospital of Wuhan University, Wuhan 430072, Hubei Province, China wiwine@sina.com
Received:2007-03-17 Accepted:2007-04-21
Abstract
Cyclooxygenase (COX) is a rate-limiting enzyme in the arachidonate metabolism. COX-2, as one of the isoenzymes of COX, is responsible for the pathogenesis, development, metastasis and prognosis of carcinoma through various mechanisms. Esophageal cancer is one of the common cancers with high incidence and high mortality. It is reported that COX-2 plays important roles in it, through xenobiotic metabolism, inhibiting apoptosis, development of inflammation-stimulated hyperplasia and metaplasia, suppressing host immune responses, inducing angiogenesis and promoting infiltration and metastasis. Recently, some trials demonstrated that selective COX-2 inhibitors can inhibit COX-2 to prevent carcinogenesis. In this article, we reviewed the roles of COX-2 in the carcinogenesis and analyzed COX-2 inhibitors for the chemoprevention of esophageal cancer.
Key Words: Esophagus cancer; Cyclooxygenase-2; Tumorigenesis; Prevention; Treatment
Hu W, Shen ZX. Advance of the relationship between esophageal cancer and cyclooxygenase-2. Shijie Huaren Xiaohua Zazhi 2007;15(15):1750-1753
摘要
环氧化酶是花生四烯酸代谢中的一种限速酶, 其中的同工酶之一的环氧合酶-2, 通过多种途径与诸多肿瘤的发生、发展和预后密切相关. 食管癌具有高发病率和死亡率, 近年来认为环氧合酶-2通过异型生物质(xenobiotic)代谢, 抑制凋亡, 参与慢性炎症、免疫抑制, 上调血管生成因子的表达, 以及促进肿瘤的浸润和转移在其致癌中起重要作用 ......
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