HBV感染垂直传播阻断研究的现状与问题
乙型肝炎病毒;垂直传播;感染,赵连三,赵连三,通讯作者:,ToeliminatedhepatitisBvirusverticaltransmission:theresolvedandunresolved,Lian-SanZhao,Corresp
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赵连三, 四川大学华西医院感染性疾病中心/生物治疗国家重点实验室 四川省成都市 610041
赵连三, 教授, 博士生导师, 主要从事感染性疾病的临床诊疗与基础实验研究. 中华医学会感染学会全国常委, 四川省医学会感染病专业委员会主任委员, 同时担任《中华传染病杂志》及《中华肝脏病杂志》等十余家中英文学术期刊编委, 发表学术论著百余篇(本).
通讯作者: 赵连三, 610041, 四川大学华西医院感染性疾病中心, 生物治疗国家重点实验室. zlsan@126.com
收稿日期: 2007-03-19 接受日期: 2007-04-13
To eliminated hepatitis B virus vertical transmission: the resolved and unresolved
Lian-San Zhao
Lian-San Zhao,Center of Infectious Diseases, National Key Laboratory of Biotherapy for Human Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Correspondence to:Lian-San Zhao, Center of Infectious Diseases, National Key Laboratory of Biotherapy for Human Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. zlsan@126.com
Received:2007-03-19 Accepted:2007-04-13
Abstract
The global prevalence of HBV (hepatitis B virus) infection is a serious public health problem. By improving concurrent hepatitis B vaccination and blood donor screening, the prevalence of HBV infection caused by horizontal transmission has been controlled. Now the prevalence of HBV predominately caused by vertical transmission from the infected pregnant women (probably, from the infected father of the fetus). For the prevention of perinatal transmission of HBV, the newborns from their mothers infected with HBV can be administered hepatitis B immune globulin (HBIG) and hepatitis B vaccine after delivery, but unfortunately, some others were still out of protection. Such failure was significantly associated with intrauterine infection of HBV.
Key Words: Hepatitis B; Vertical transmission; Infection
Zhao LS. To eliminated hepatitis B virus vertical transmission: the resolved and unresolved. Shijie Huaren Xiaohua Zazhi 2007;15(15):1677-1681
摘要
乙型肝炎病毒(HBV)感染是严重的公共卫生问题. 随着献血管理的加强和乙肝疫苗的逐步推广, HBV感染水平传播的流行势头已经得到遏制, 而垂直传播成为导致HBV慢性感染的主要途径之一 ......
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