胃癌组织中Caveolin-1, nm23及MMP-2的表达及其意义
胃肿瘤;Caveolin-1;nm23;基质金属蛋白酶-2;免疫组织化学,胃癌组织中Caveolin-1,nm23及MMP-2的表达及其意义,杨育生,刘斌,邢传平,高自芳,顾立萍,钱震,董亮,苏勤军,杨育生,通讯作者:,ExpressionsandsignificancesofCaveoli
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杨育生, 刘斌, 邢传平, 高自芳, 顾立萍, 钱震, 董亮, 苏勤军, 兰州军区兰州总医院病理科 甘肃省兰州市 730050
杨育生, 硕士研究生, 主要从事临床病理和肿瘤相关研究.
全军医药卫生科研基金资助项目, No. 06MB102
甘肃省自然科学基金资助课题, No. 3ZS061-A25-094
通讯作者: 刘斌, 730050, 甘肃省兰州市, 兰州军区兰州总医院病理科. liumb@public.lz.gs.cn
电话: 0931-8975406 传真: 0931-8975404
收稿日期: 2007-03-12 接受日期: 2007-03-31
Expressions and significances of Caveolin-1, nm23 and matrix metalloproteinase -2 in gastric carcinomas
Yu-Sheng Yang, Bin Liu, Chuan-Ping Xing, Zi-Fang Gao, Li-Ping Gu, Zhen Qian, Liang Dong, Qin-Jun Su
Yu-Sheng Yang, Bin Liu, Chuan-Ping Xing, Zi-Fang Gao, Li-Ping Gu, Zhen Qian, Liang Dong, Qin-Jun Su,Department of Pathology, General Hospital of Lanzhou Military Command, Chinese PLA, Lanzhou 730050, Gansu Province, China
Supported bythe Military Medical and Health Research Foundation, No. 06MB102, and the Natural Science Foundation of Gansu Province, No. 3ZS061-A25-094
Correspondence to:Bin Liu, Department of Pathology, General Hospital of Lanzhou Military Command, Chinese PLA, Lanzhou 730050, Gansu Province, China. liumb@public.lz.gs.cn
Received:2007-03-12 Accepted:2007-03-31
Abstract
AIM: To investigate the protein expression of Caveolin-1, nm23 and matrix metalloproteinase-2 (MMP-2) in normal gastric mucosa, gastric atypical hyperplasia and gastric carcinoma tissues.
METHODS: S-P immunohistochemical method was used to detect the expression of Caveolin-1, nm23 and MMP-2 proteins in normal gastric mucosa (n = 25), gastric atypical hyperplasia (n = 65), and gastric carcinomas (n = 71).
RESULTS: Caveolin-1 and nm23 expression showed a decreasing tendency in normal gastric mucosa, atypical hyperplasia and gastric cancer tissues ordinarily, and there were statistical differences between groups (χ2 = 106.303, P < 0.05; χ2 = 64.254, P < 0.05). However, MMP-2 expression exhibited a increasing tendency (χ2 = 35 ......
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