促愈颗粒对大鼠乙酸胃溃疡愈合质量的影响
促愈颗粒;胃溃疡;再生黏膜;溃疡愈合质量;一氧化氮;前列腺素E2;表皮生长因子;超微结构;放射免疫法;免疫组织化学,时昭红,张介眉,周慧芳,杨海芳,陈洲,冯云霞,时昭红,通讯作者:,EffectofCuyugranuleonthequalityof
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时昭红, 张介眉, 武汉市第一医院消化内科 湖北省武汉市 430022
周慧芳, 杨海芳, 陈洲, 冯云霞, 湖北中医学院中医系 湖北省武汉市 430061
时昭红, 2006年湖北中医学院中医内科学博士, 主要从事消化系统疾病的诊治研究.
通讯作者: 时昭红, 430022, 湖北省武汉市中山大道375号, 武汉市第一医院消化内科. zhaohshi@sohu.com
电话: 027-85855908-907
收稿日期: 2006-09-11 接受日期: 2007-01-10
Effect of Cuyu granule on the quality of ulcer healing in tats with gastric ulcer induced by acetic acid
Zhao-Hong Shi, Jie-Mei Zhang, Hui-Fang Zhou, Hai-Fang Yang, Zhou Chen, Yun-Xia Feng
Zhao-Hong Shi, Jie-Mei Zhang,Department of Gastroenterology, Wuhan First Municipal Hospital, Wuhan 430022, Hubei Province, China
Hui-Fang Zhou, Hai-Fang Yang, Zhou Chen, Yun-Xia Feng,Hubei College of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China
Correspondence to:Zhao-Hong Shi, Department of Gastroenterology, Wuhan First Municipal Hospital, 375 Zhongshan Avenue, Wuhan 430022, Hubei Province, China. zhaohshi@sohu.com
Received:2006-09-11 Accepted:2007-01-10
Abstract
AIM: To investigate the effect of Cuyu granule (CYG) on the quality of ulcer healing (QOUH) in rats.
METHODS: Rat model of chronic gastric ulcer was induced by acetic acid and all the rats were randomly divided into 4 groups, named group A (control), B (model), C (treated with ranitidine) and D (treated with CYG), respectively. The numbers of distended glands and inflammatory cells of healed gastric mucosa in rats were observed by HE staining, and the contents of nitric oxide (NO) in serum and prostaglandin E2 (PGE2) in plasma were determined by the nitric acid reductase process and radioimmunoassay (RIA) respectively. The protein expression of epidermal growth factor (EGF) was examined by immunohistochemistry, and the ultra-structure of regenerative mucosa was observed by transmission electronic microscopy.
RESULTS: Twenty-eight days after drug administration, the numbers of distended glands and inflammatory cells in group D were significantly decreased in comparison with those in group B and C (distended glands: 1 ......
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