银杏天宝对大鼠实验性结肠炎抗氧化作用的影响
银杏天宝;溃疡性结肠炎;氧自由基;抗氧化;一氧化氮,周燕红,于皆平,周燕红,通讯作者:,EffectsofGinkgobilobaextractontheantioxidationinratswithTNBS-inducedcolitis
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周燕红, 咸宁学院医学院消化内科 湖北省咸宁市 437100
于皆平, 武汉大学人民医院消化内科 湖北省武汉市 430060
周燕红, 副主任医师, 副教授, 博士, 主要从事溃疡性结肠炎的基础和临床研究.
湖北省教育厅资助项目, No. B200528003
通讯作者: 周燕红, 437100, 湖北省咸宁市, 咸宁学院医学院消化内科. yanhongzhou326@yahoo.com.cn
电话: 027-63314906
收稿日期: 2007-03-12 接受日期: 2007-03-29
Effects of Ginkgo biloba extract on the antioxidation in rats with TNBS-induced colitis
Yan-Hong Zhou, Jie-Ping Yu
Yan-Hong Zhou,Department of Gastroenterology, Medical College of Xianning University, Xianning 437100, Hubei Province, China
Jie-Ping Yu,Department of Gastroenterology, People’s Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Supported bythe Foundation from Education Department of Hubei Province, No. B200528003
Correspondence to:Yan-Hong Zhou, Department of Gastroenterology, Medical College of Xianning University, Xianning 437100, Hubei Province, China. yanhongzhou326@yahoo.com.cn
Received:2007-03-12 Accepted:2007-03-29
Abstract
AIM: To investigate the therapeutic effect and antioxidation mechanism of Ginkgo biloba extract (EGB) in rats with ulcerative colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS).
METHODS: Rat model of ulcerative colitis was induced by 2, 4, 6-trinitrobenzene sulfonic acid (150 mg/kg) with ethanol. The experimental animals were randomly divided into 4 groups: normal group, model group, 5-aminosalicylic acid (5-ASA, 100 mg/kg) group, EGB (200 mg/kg) group. The macroscopic and histological damages were evaluated. The contents of malondiadehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and glutathion peroxide (GSH-Px) were measured by biochemical methods. The expression of inducible nitric oxide synthase (iNOS) in the colon tissues was detected by immunchistochemistry.
RESULTS: The expression of iNOS (19.60% ± 3.17% vs 81.36% ± 1.71%), the tissue contents of NO (9 ......
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