DNA损伤与肝癌发生
DNA损伤;DNA修复;肝癌发生,朱德强,黄志勇,黄志勇,通讯作者:,DNAdamageandlivercancer,De-QiangZhu,Zhi-YongHuang,Supportedby,Correspondenceto:,Received:,Accepted
参见附件(518kb)。
朱德强, 黄志勇, 华中科技大学同济医学院附属同济医院肝脏外科中心 湖北省武汉市 430030
黄志勇, 教授, 1996年获同济医科大学医学博士学位, 1999/2002在美国从事博士后研究, 主要从事肝脏外科、肝癌发生的分子机制及治疗研究.
教育部新世纪优秀人才支持计划资助项目, No. NCET-04-0701
通讯作者: 黄志勇, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院肝脏外科中心. zyhuang@medmail.com.cn
电话: 027-83663871 传真: 027-83803209
收稿日期: 2007-05-18 接受日期: 2007-05-30
DNA damage and liver cancer
De-Qiang Zhu, Zhi-Yong Huang
De-Qiang Zhu, Zhi-Yong Huang, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by The New Centaury Excellent Talent Foundation from Ministry of Education, No. NCET-04-0701
Correspondence to: Dr. Zhi-Yong Huang, Center of Hepatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zyhuang@medmail.com.cn
Received: 2007-05-18 Accepted: 2007-05-30
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Carcinogenesis of HCC involves complex biological processes for which the mechanism/s remains to be completely clarified. Research has shown that hepatitis B and C virus infections, aflatoxin contamination, alcohol abuse, ionizing radiation and human metabolic products toxic to the human genome can induce HCC. Most of these cause DNA damage by having direct impacts on the genetic materials of hepatocytes. This constitutes an important molecular basis for the carcinogenesis of HCC. DNA damage causes a series of cell responses, including injury signal transduction, damage repair, and induction of cell death. The factors involved in DNA damage can also affect some aspects of the DNA injury repair system, preventing the damage from being repaired or correctly repaired, leading to malignant transformations. Therefore, the accumulation of damaged DNA becomes an important molecular mechanism underlying the carcinogenesis of HCC. Further studies should lay a foundation for research into treatments for HCC.
Key Words: DNA damage; DNA repair; Hepatocellular carcinoma
Zhu DQ, Huang ZY. DNA damage and liver cancer. Shijie Huaren Xiaohua Zazhi 2007;15(16):1775-1780
摘要
肝癌是最常见的恶性肿瘤之一, 其发生是一个复杂的生物学过程, 具体机制尚未完全阐明. 研究表明, 乙、丙型肝炎病毒感染, 黄曲霉毒素污染, 饮酒, 电离辐射以及具有有遗传毒性的人体代谢产物等能够诱导肝癌的发生, 他们大都直接作用于肝细胞的遗传物质, 引起DNA的损伤, 这是发生肝癌的重要分子基础. DNA损伤后引起细胞一系列的反应, 包括损伤信号的传导, 损伤修复, 诱导细胞死亡. 这些诱因也能作用于损伤修复系统中的某个环节, 使DNA损伤不能修复或不能正确修复, 细胞发生恶性转化. 因此, 损伤DNA的累积就成为肝癌发生的重要分子机制, 对其深入研究将会为肝癌的治疗奠定基础.
关键词: DNA损伤; DNA修复; 肝癌发生
朱德强, 黄志勇. DNA损伤与肝癌发生. 世界华人消化杂志 2007;15(16):1775-1780
0 引言
人体细胞经常受到多种体内外因子的损伤, 如电离辐射(IR), 紫外线(UV)等物理因素, 烷化剂, 亚硝胺类等各种化学因素, 病毒感染等生物因素. 这些因素中具有遗传毒性的物质会造成各种各样的DNA损伤, 如单、双链缺口(SSB, DSB), 碱基突变, 碱基氧化损伤等. 如果损伤被正确修复, 细胞存活, 如果修复过程中出现缺失、插入等不正确的修复, 这些异常碱基的累积就可能导致癌症的发生. 如果损伤严重不能修复, 细胞就会启动凋亡程序, 诱导细胞死亡, 这条通路也被认为是阻止细胞恶性转化的最后一道屏障 ......
朱德强, 黄志勇, 华中科技大学同济医学院附属同济医院肝脏外科中心 湖北省武汉市 430030
黄志勇, 教授, 1996年获同济医科大学医学博士学位, 1999/2002在美国从事博士后研究, 主要从事肝脏外科、肝癌发生的分子机制及治疗研究.
教育部新世纪优秀人才支持计划资助项目, No. NCET-04-0701
通讯作者: 黄志勇, 430030, 湖北省武汉市解放大道1095号, 华中科技大学同济医学院附属同济医院肝脏外科中心. zyhuang@medmail.com.cn
电话: 027-83663871 传真: 027-83803209
收稿日期: 2007-05-18 接受日期: 2007-05-30
DNA damage and liver cancer
De-Qiang Zhu, Zhi-Yong Huang
De-Qiang Zhu, Zhi-Yong Huang, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by The New Centaury Excellent Talent Foundation from Ministry of Education, No. NCET-04-0701
Correspondence to: Dr. Zhi-Yong Huang, Center of Hepatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zyhuang@medmail.com.cn
Received: 2007-05-18 Accepted: 2007-05-30
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Carcinogenesis of HCC involves complex biological processes for which the mechanism/s remains to be completely clarified. Research has shown that hepatitis B and C virus infections, aflatoxin contamination, alcohol abuse, ionizing radiation and human metabolic products toxic to the human genome can induce HCC. Most of these cause DNA damage by having direct impacts on the genetic materials of hepatocytes. This constitutes an important molecular basis for the carcinogenesis of HCC. DNA damage causes a series of cell responses, including injury signal transduction, damage repair, and induction of cell death. The factors involved in DNA damage can also affect some aspects of the DNA injury repair system, preventing the damage from being repaired or correctly repaired, leading to malignant transformations. Therefore, the accumulation of damaged DNA becomes an important molecular mechanism underlying the carcinogenesis of HCC. Further studies should lay a foundation for research into treatments for HCC.
Key Words: DNA damage; DNA repair; Hepatocellular carcinoma
Zhu DQ, Huang ZY. DNA damage and liver cancer. Shijie Huaren Xiaohua Zazhi 2007;15(16):1775-1780
摘要
肝癌是最常见的恶性肿瘤之一, 其发生是一个复杂的生物学过程, 具体机制尚未完全阐明. 研究表明, 乙、丙型肝炎病毒感染, 黄曲霉毒素污染, 饮酒, 电离辐射以及具有有遗传毒性的人体代谢产物等能够诱导肝癌的发生, 他们大都直接作用于肝细胞的遗传物质, 引起DNA的损伤, 这是发生肝癌的重要分子基础. DNA损伤后引起细胞一系列的反应, 包括损伤信号的传导, 损伤修复, 诱导细胞死亡. 这些诱因也能作用于损伤修复系统中的某个环节, 使DNA损伤不能修复或不能正确修复, 细胞发生恶性转化. 因此, 损伤DNA的累积就成为肝癌发生的重要分子机制, 对其深入研究将会为肝癌的治疗奠定基础.
关键词: DNA损伤; DNA修复; 肝癌发生
朱德强, 黄志勇. DNA损伤与肝癌发生. 世界华人消化杂志 2007;15(16):1775-1780
0 引言
人体细胞经常受到多种体内外因子的损伤, 如电离辐射(IR), 紫外线(UV)等物理因素, 烷化剂, 亚硝胺类等各种化学因素, 病毒感染等生物因素. 这些因素中具有遗传毒性的物质会造成各种各样的DNA损伤, 如单、双链缺口(SSB, DSB), 碱基突变, 碱基氧化损伤等. 如果损伤被正确修复, 细胞存活, 如果修复过程中出现缺失、插入等不正确的修复, 这些异常碱基的累积就可能导致癌症的发生. 如果损伤严重不能修复, 细胞就会启动凋亡程序, 诱导细胞死亡, 这条通路也被认为是阻止细胞恶性转化的最后一道屏障 ......
您现在查看是摘要介绍页，详见PDF附件(518kb)。