细胞色素P4502E1酶与非酒精性脂肪肝的关系
非酒精性脂肪性肝病;基因多态性;细胞色素P4502E1,郭艳梅,王沁,祁志,通讯作者:,AssociationofCYP2E1enzymesandsusceptibilityfornon-alcoholicliverdisease,Yan-Mei
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郭艳梅, 甘肃中医学院临床医疗系 甘肃省兰州市 730000
王沁, 祁志, 兰州大学第一医院消化科 甘肃省兰州市 730000
郭艳梅, 2004级兰州大学临床医学院硕士研究生, 主要从事酒精性肝病研究.
通讯作者: 郭艳梅, 730000, 甘肃中医学院临床医疗系. guoyanmei100@126.com
电话: 0931-8625200
收稿日期: 2007-02-02 接受日期: 2007-03-17
Association of CYP2E1 enzymes and susceptibility for non-alcoholic liver diseaseYan-Mei Guo, Qin Wang, Zhi Qi
Yan-Mei Guo, Department of Clinical Medicine, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Qin Wang, Zhi Qi, Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Correspondence to: Yan-Mei Guo, Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China. guoyanmei100@126.com
Received: 2007-02-02 Accepted: 2007-03-17
Abstract
AIM: To investigate correlations between cytochrome P4502E1 (CYP2E1) enzyme gene polymorphisms and non-alcoholic fatty liver disease (NAFLD).
METHODS: A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determined polymorphisms of CYP2E1 PstⅠ and RsaⅠ sites.
RESULTS: Genotypes were separated into three: type A (homozygous for c1 gene), type B (heterozygous for c1/c2 gene), and type C (homozygous for c2 gene). In 20 healthy controls, c1 frequency was 85.0% and c2 15.0%. In 40 patients with NAFLD, c1 was 58.8% and c2 41.2%. Comparing the NAFLD group with the healthy controls, c1 was decreased and c2 increased, significantly (P = 0.004). Comparing the NAFLD group with the alcoholic liver disease group, the frequency of the c2 allele gene was not significantly different (P = 0.896). In the NAFLD group the frequency of the c2 allele gene increased with the degree of pathogenesis of liver disease (P = 0.000).
CONCLUSION: The genetic polymorphism of CYP2E1 at the PstⅠ and RsaⅠ sites is associated with susceptibility for NAFLD ......
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