快速乙型肝炎疫苗接种程序分析
乙型病毒性肝炎疫苗;快速免疫;免疫应答;接种方案,陈仕珠,张晋红,任菊香,温风玲,刘振霞,任雪莲,通讯作者:,AnalysisonacceleratedhepatitisBimmunizationschedule,Shi-ZhuChen,Jin-HongZhang
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陈仕珠, 张晋红, 任菊香, 温风玲, 刘振霞, 任雪莲, 中国人民解放军第451医院感染病科 陕西省西安市 710054
通讯作者: 陈仕珠, 710054, 陕西省西安市友谊东路269号, 中国人民解放军第451医院感染病科. chenshizhu34419@126.com
电话: 029-84734222
收稿日期: 2007-04-06 接受日期: 2007-04-28
Analysis on accelerated hepatitis B immunization schedule Shi-Zhu Chen, Jin-Hong Zhang, Ju-Xiang Ren, Feng-Ling Wen, Zhen-Xia Liu, Xue-Lian Ren
Shi-Zhu Chen, Jin-Hong Zhang, Ju-Xiang Ren, Feng-Ling Wen, Zhen-Xia Liu, Xue-Lian Ren, Department of Infectious Diseases, Chinese PLA 451st Hospital, Xi’an 710054, Shaanxi Province, China
Correspondence to: Shi-Zhu Chen, Department of Infectious Diseases, Chinese PLA 451st Hospital, Xi’an 710054, Shaanxi Province, China. chenshizhu34419@126.com
Received: 2007-04-06 Accepted: 2007-04-28
Abstract
AIM: To analyze the effect of accelerated immunization schedule for those who have no responses to standard hepatitis B vaccination schedule.
METHODS: Healthy subjects were divided into group A (n = 53) and B (n = 48), vaccinated by 30 µg (20 µg for those less than 12 years old) recombinant hepatitis B vaccine with the accelerated schedule (immunized on day 0, 7, 14) and standard schedule (immunized in month 0, 1, 6), respectively. The efficacy was detected 1, 3, 7, 12, 24 and 36 months after the first vaccination.
RESULTS: The seroconversion rates and protection rates in group A were significantly higher than those in group B 1, 3 and 7 month after the first vaccination (64.2%, 66.0%, 61.5% vs 0%, 16.7%, 52.1%; 54.7%, 54.7%, 47.3% vs 0%, 4.1%, 40.1%; P < 0.01). The completion rate and geometric titer (GMT) of anti-HBs 1 and 3 month after the first dose in group A were also markedly higher than those in group B (100% vs 60 ......
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