生长抑素类似物对大鼠急性胰腺炎PAP的影响
生长抑素类似物;急性胰腺炎;胰腺炎相关蛋白;大鼠,佟柏峰,周昊昕,邹小明,彭海,周文学,杨维良,通讯作者:,Influenceofsomatostatinanologueonpancreatitis-associatedproteininratswith
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佟柏峰, 周昊昕, 邹小明, 彭海, 周文学, 杨维良, 哈尔滨医科大学附属第二医院普外科 黑龙江省哈尔滨市 150086
佟柏峰, 2002年哈尔滨医科大学硕士毕业, 讲师, 参与国家课题猪胰岛移植和猪异种小肠移植等工作.
中华医学会年胰腺外科科研项目基金(2005)
通讯作者: 邹小明, 150086, 黑龙江省哈尔滨市, 哈尔滨医科大学附属第二医院普外科.
电话: 0451-86605726
收稿日期: 2006-11-22 接受日期: 2007-01-31
Influence of somatostatin anologue on pancreatitis-associated protein in rats with acute pancreatitis
Bai-Feng Tong, Hao-Xin Zhou, Xiao-Ming Zou, Hai Peng, Wen-Xue Zhou, Wei-Liang Yang
Bai-Feng Tong, Hao-Xin Zhou, Xiao-Ming Zou, Hai Peng, Wen-Xue Zhou, Wei-Liang Yang, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Supported by the Pancreatic Surgery Research Foundation of Chinese Medical Association (2005)
Correspondence to: Xiao-Ming Zou, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Received: 2006-11-22 Accepted: 2007-01-31
Abstract
AIM: To investigate the influence of somatostatin anologue octreotide on the expression of pancreatitis-associated protein (PAP) and pathological changes in pancreas in rats with acute pancreatitis (AP). Then the level of serum PAP was measured by enzyme-linked immunosorbent assay (ELISA).
METHODS: Eighty Wistar rats were randomized into group A, B, C and D, served as negative control group, sham operation group, AP model group and octreotide-treated group, respectively. The experimental samples were collected at the 6th and 12th hour in all the groups. The expression of PAP in pancreas was detected by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) after the AP tissues were verified by pathological method. Then the level of serum PAP was measured by enzyme-linked immunosorbent assay (ELISA) ......
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