大肠癌胃泌素、生长抑素的表达及比势与细胞周期调控基因的相关性
大肠癌;胃泌素;生长抑素;P16INK4a;P21CIP1;细胞周期素;细胞周期依赖性蛋白激酶,吴佩,茆家定,梁林虎,闫竞一,吴佩,通讯作者:,Correlationsamonggastrinandsomatostatinexpres
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吴佩, 茆家定, 梁林虎, 闫竞一, 皖南医学院弋矶山医院普外科 安徽省芜湖市 241001
吴佩, 硕士研究生导师, 教授, 主任医师, 研究方向为胃肠激素与消化道肿瘤.
安徽省自然科学基金资助项目, No. 03043740
安徽省教育厅自然科学基金资助项目, No. 2006Kj115c
通讯作者: 茆家定, 241001, 安徽省芜湖市赭山西路93号, 皖南医学院弋矶山医院普外科. maojiading0205@sina.com
电话: 0553-5739343
收稿日期: 2007-03-30 接受日期: 2007-04-13
Correlations among gastrin and somatostatin expressions and the cell cycle: controlling genes in large intestine carcinomas
Pei Wu, Jia-Ding Mao, Lin-Hu Liang, Jing-Yi Yan
Pei Wu, Jia-Ding Mao, Lin-Hu Liang, Jing-Yi Yan, Department of General Surgery, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China
Supported by: the Natural Science Foundation of Anhui Province, No. 03043704 and the Natural Science Foundation of Education Bureau of Anhui Province, No. 2006Kj115c
Correspondence to: Jia-Ding Mao, Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China. maojiading0205@sina.com
Received: 2007-03-30 Accepted: 2007-04-13
Abstract
AIM: To explore correlations among the expression of gastrin (GAS), somatostatin (SS), P16INK4a, P21CIP1, Cyclins, and Cyclin-dependent-kinases (CDKs) in large intestine carcinomas.
METHODS: Seventy-nine resected large intestine carcinomatous specimens were randomly selected. GAS, SS, p16INK4a, p21CIP1, Cyclin D1, Cyclin E, Cyclin A, Cyclin B1, CDK2, and CDK4 were detected by immunohistochemistry (Streptavidin-Peroxidase, SP).
RESULTS: Positive expression rates of Cyclin D1, CDK2, CDK4, and Cyclin A were significantly higher in cases showing high or medium expression levels of GAS than in cases with low GAS expression. The positive expression rates of P16INK4a and P21CIP1 were the reverse. The positive expression rate of Cyclin E was significantly lower in the high and middle SS expression groups than in the low SS expression group ......
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