胃癌树突状细胞浸润的临床意义及与肿瘤血管生成的相关性
胃癌;树突状细胞;血管内皮生长因子;微血管密度;免疫组织化学,周业江,梁建群,綦晓龙,易国平,李显蓉,魏仁智,熊玉霞,周业江,通讯作者:,Infiltratingdendriticcellsinthedevelopmentofgastric
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周业江, 梁建群, 綦晓龙, 易国平, 李显蓉, 魏仁智, 泸州医学院附属医院普外科 四川省泸州市 646000
熊玉霞, 泸州医学院药理教研室 四川省泸州市 646000
周业江, 泸州医学院附属医院普外科副教授, 医学博士, 硕士研究生导师, 主要从事胃肠肿瘤的基础与临床研究.
国家自然科学基金资助项目, No. 30672058
通讯作者: 周业江, 646000, 四川省泸州市, 泸州医学院附属医院普外科. zyj7525@163.com
电话: 0830-3165421
收稿日期: 2007-02-02 接受日期: 2007-03-17
Infiltrating dendritic cells in the development of gastric cancer and an association with tumor angiogenesis
Ye-Jiang Zhou, Jian-Qun Liang, Xiao-Long Qi, Yu-Xia Xiong, Guo-Ping Yi, Xian-Rong Li, Ren-Zhi Wei
Ye-Jiang Zhou, Jian-Qun Liang, Xiao-Long Qi, Guo-Ping Yi, Xian-Rong Li, Ren-Zhi Wei, Department of General Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Yu-Xia Xiong, Department of Pharmacy, Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Supported by: National Natural Science Foundation, No. 30672058
Correspondence to: Ye-Jiang Zhou, 646000, Department of General Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China. zyj7525@163.com
Received: 2007-02-02 Accepted: 2007-03-17
Abstract
AIM: To investigate the potential role of infiltrating dendritic cells (DCs) in the biological behavior of gastric cancer and any association with tumor angiogenesis.
METHODS: Immunohistological identification of DCs in gastric cancer using monoclonal antibody recognizing S-100 protein was undertaken in 35 primary gastric cancers (PGC) and 23 lymphoid metastatic gastric cancers (LMGC). Antibodies recognizing vascular endothelial growth factor (VEGF) and CD34 were employed to detect VEGF expression and microvascular density (MVD), respectively.
RESULTS: The density of S-100+DCs was obviously decreased along with progressive cancer invasion of the gastric wall; a statistically significant decrease was seen in gastric cancer with serosal invasion (P = 0 ......
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